Osteocyte biology

Its implications for osteoporosis

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Osteocyte viability may play a significant role in the maintenance and integrity of bone. Bone loss due to osteoporosis may be due in part to osteocyte cell death. We have identified a factor that will protect both osteoblasts and osteocytes from cell death due to agents known to be responsible for various forms of osteoporosis. Not only does estrogen preserve osteoblast and osteocyte viability, but so does a molecule called CD40Ligand. This molecule is expressed on activated T lymphocytes, human dendritic cells, and human vascular endothelial cells, whereas its receptor CD40 is expressed on normal epithelium, B cells, and dendritic cells. CD40Ligand protects osteoblasts and the MLO-Y4 osteocyte-like cells against apoptosis induced by glucocorticoids, tumor necrosis factor α or etoposide. As tumor necrosis factor a has been shown to be responsible for post-menopausal bone loss and glucocorticoids induce dramatic bone loss, this finding has important implications with regards to potential therapy for both post-menopausal and steroid-induced osteoporosis.

Original languageEnglish (US)
Pages (from-to)101-104
Number of pages4
JournalJournal of Musculoskeletal Neuronal Interactions
Volume4
Issue number1
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Osteocytes
Osteoporosis
Osteoblasts
Bone and Bones
Dendritic Cells
Glucocorticoids
Cell Death
Tumor Necrosis Factor-alpha
Etoposide
Estrogens
B-Lymphocytes
Epithelium
Endothelial Cells
Steroids
Maintenance
Apoptosis
T-Lymphocytes

Keywords

  • Apoptosis
  • Bone resorption
  • CD40Ligand
  • Osteocyte
  • Osteoporosis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Endocrinology

Cite this

Osteocyte biology : Its implications for osteoporosis. / Bonewald, Lynda.

In: Journal of Musculoskeletal Neuronal Interactions, Vol. 4, No. 1, 03.2004, p. 101-104.

Research output: Contribution to journalArticle

@article{578bb9cfa01e4592840c2052318a5bc9,
title = "Osteocyte biology: Its implications for osteoporosis",
abstract = "Osteocyte viability may play a significant role in the maintenance and integrity of bone. Bone loss due to osteoporosis may be due in part to osteocyte cell death. We have identified a factor that will protect both osteoblasts and osteocytes from cell death due to agents known to be responsible for various forms of osteoporosis. Not only does estrogen preserve osteoblast and osteocyte viability, but so does a molecule called CD40Ligand. This molecule is expressed on activated T lymphocytes, human dendritic cells, and human vascular endothelial cells, whereas its receptor CD40 is expressed on normal epithelium, B cells, and dendritic cells. CD40Ligand protects osteoblasts and the MLO-Y4 osteocyte-like cells against apoptosis induced by glucocorticoids, tumor necrosis factor α or etoposide. As tumor necrosis factor a has been shown to be responsible for post-menopausal bone loss and glucocorticoids induce dramatic bone loss, this finding has important implications with regards to potential therapy for both post-menopausal and steroid-induced osteoporosis.",
keywords = "Apoptosis, Bone resorption, CD40Ligand, Osteocyte, Osteoporosis",
author = "Lynda Bonewald",
year = "2004",
month = "3",
language = "English (US)",
volume = "4",
pages = "101--104",
journal = "Journal of Musculoskeletal Neuronal Interactions",
issn = "1108-7161",
publisher = "International Society of Musculoskeletal and Neuronal Interactions",
number = "1",

}

TY - JOUR

T1 - Osteocyte biology

T2 - Its implications for osteoporosis

AU - Bonewald, Lynda

PY - 2004/3

Y1 - 2004/3

N2 - Osteocyte viability may play a significant role in the maintenance and integrity of bone. Bone loss due to osteoporosis may be due in part to osteocyte cell death. We have identified a factor that will protect both osteoblasts and osteocytes from cell death due to agents known to be responsible for various forms of osteoporosis. Not only does estrogen preserve osteoblast and osteocyte viability, but so does a molecule called CD40Ligand. This molecule is expressed on activated T lymphocytes, human dendritic cells, and human vascular endothelial cells, whereas its receptor CD40 is expressed on normal epithelium, B cells, and dendritic cells. CD40Ligand protects osteoblasts and the MLO-Y4 osteocyte-like cells against apoptosis induced by glucocorticoids, tumor necrosis factor α or etoposide. As tumor necrosis factor a has been shown to be responsible for post-menopausal bone loss and glucocorticoids induce dramatic bone loss, this finding has important implications with regards to potential therapy for both post-menopausal and steroid-induced osteoporosis.

AB - Osteocyte viability may play a significant role in the maintenance and integrity of bone. Bone loss due to osteoporosis may be due in part to osteocyte cell death. We have identified a factor that will protect both osteoblasts and osteocytes from cell death due to agents known to be responsible for various forms of osteoporosis. Not only does estrogen preserve osteoblast and osteocyte viability, but so does a molecule called CD40Ligand. This molecule is expressed on activated T lymphocytes, human dendritic cells, and human vascular endothelial cells, whereas its receptor CD40 is expressed on normal epithelium, B cells, and dendritic cells. CD40Ligand protects osteoblasts and the MLO-Y4 osteocyte-like cells against apoptosis induced by glucocorticoids, tumor necrosis factor α or etoposide. As tumor necrosis factor a has been shown to be responsible for post-menopausal bone loss and glucocorticoids induce dramatic bone loss, this finding has important implications with regards to potential therapy for both post-menopausal and steroid-induced osteoporosis.

KW - Apoptosis

KW - Bone resorption

KW - CD40Ligand

KW - Osteocyte

KW - Osteoporosis

UR - http://www.scopus.com/inward/record.url?scp=2642583402&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2642583402&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 101

EP - 104

JO - Journal of Musculoskeletal Neuronal Interactions

JF - Journal of Musculoskeletal Neuronal Interactions

SN - 1108-7161

IS - 1

ER -