Osteocyte death

A beacon for targeted remodeling

Research output: Contribution to journalArticle

Abstract

It has been long proposed that the osteocyte network continually compares present mechanical strains to usual levels of strain, and triggers signals to osteoclasts or osteoblasts resulting in bone loss or gain, as needed. Whereas physiological levels of mechanical stimulation maintain bone mass, too low or too high levels of strain induce bone resorption. One mechanism by which osteocytes may trigger bone resorption is by undergoing apoptosis. Either low or high levels of mechanical loading lead to increased prevalence of osteocyte apoptosis, which temporally precedes and is spatially associated with osteoclast recruitment and the subsequent increase in bone resorption.1,2 Moreover, a cause and effect relationship between osteocyte death and bone resorption has been recently demonstrated. Using a transgenic mouse model of inducible osteocyte ablation, Tatsumi et al.3 show that osteocyte apoptosis is sufficient to trigger osteoclast recruitment and bone resorption. Moreover, the normal osteoclastogenic response to unloading is missing in bones from osteocyte-depleted mice, confirming that osteocytes are indispensable for the skeletal adaptation to weightlessness. Because osteocyte apoptosis is inhibited not only by mechanical stimulation but also by estrogens and bisphosphonates, these findings raise the intriguing possibility that preservation of osteocyte viability contributes to the anti-remodeling properties of these agents.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalActualizaciones en Osteologia
Volume5
Issue number1
StatePublished - Jul 2009

Fingerprint

Osteocytes
Bone Resorption
Osteoclasts
Apoptosis
Bone and Bones
Weightlessness
Diphosphonates
Osteoblasts
Transgenic Mice
Estrogens

Keywords

  • Apoptosis
  • Osteocytes
  • Remodeling

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine (miscellaneous)

Cite this

Osteocyte death : A beacon for targeted remodeling. / Bellido, Teresita.

In: Actualizaciones en Osteologia, Vol. 5, No. 1, 07.2009, p. 21-24.

Research output: Contribution to journalArticle

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