Osteocitos y la regulación de la formación Ósea

Translated title of the contribution: Osteocytes and regulation of bone formation

Teresita Bellido, Gretel Pellegrini

Research output: Contribution to journalArticle

Abstract

For many years, osteocytes have been the forgotten bone cells and considered as inactive spectators buried in the bone matrix. We now know that osteocytes detect and respond to mechanical and hormonal stimuli to coordinate bone resorption and bone formation. Osteocytes are currently considered a major source of molecules that regulate the activity of osteoclasts and osteoblasts, such as RANKL and sclerostin; and genetic and pharmacological manipulations of either molecule markedly affect bone homeostasis. This article summarizes recent findings demonstrating the mechanisms by which osteocytes regulate the number and activity of osteoblasts and thus affect bone formation.

Original languageSpanish
Pages (from-to)423-427
Number of pages5
JournalActa Bioquimica Clinica Latinoamericana
Volume50
Issue number3
StatePublished - Sep 2016

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Keywords

  • Bone remodeling
  • Osteoblast
  • Osteoclast
  • Osteocyte
  • Sost gene
  • Wnt signaling

ASJC Scopus subject areas

  • Clinical Biochemistry

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