Osteocytes as dynamic multifunctional cells

Research output: Chapter in Book/Report/Conference proceedingConference contribution

208 Citations (Scopus)

Abstract

The target of bone systemic factors and therapeutics has been assumed to be primarily osteoblasts and/or osteoclasts and their precursors. All the action with regard to bone modeling or remodeling has been assumed to take place on the bone surface. In this scenario, cells below the bone surface, that is, osteocyte, are considered to be inactive placeholders in the bone matrix. New data show osteocytes are involved. In addition to the function of osteocytes translating mechanical strain into biochemical signals between osteocytes and cells on the bone surface to affect (re)modeling, new functions are emerging. Osteocytes are exquisitely sensitive to mechanical strain in the form of shear stress compared to osteoblasts or osteoclasts and communicate with each other, with cells on the bone surface, and with marrow cells. Osteocytes are able to move their cell body and their dendritic processes and appear to be able to modify their local microenvironment. A novel function now attributed to osteocytes includes regulation of phosphate metabolism. Therefore, in addition to osteoblasts and osteoclasts, osteocytes are also important for bone health.

Original languageEnglish (US)
Title of host publicationSkeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling
Pages281-290
Number of pages10
Volume1116
DOIs
StatePublished - Nov 2007
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1116
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Osteocytes
Bone
Bone and Bones
Osteoblasts
Osteoclasts
Cells
Bone Matrix
Metabolism
Shear stress
Bone Marrow
Phosphates
Health

Keywords

  • Dmp1
  • E11/gp38
  • FGF23
  • Mechanical load
  • Osteocytes
  • Perilacunar matrix
  • Pex

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bonewald, L. (2007). Osteocytes as dynamic multifunctional cells. In Skeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling (Vol. 1116, pp. 281-290). (Annals of the New York Academy of Sciences; Vol. 1116). https://doi.org/10.1196/annals.1402.018

Osteocytes as dynamic multifunctional cells. / Bonewald, Lynda.

Skeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling. Vol. 1116 2007. p. 281-290 (Annals of the New York Academy of Sciences; Vol. 1116).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bonewald, L 2007, Osteocytes as dynamic multifunctional cells. in Skeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling. vol. 1116, Annals of the New York Academy of Sciences, vol. 1116, pp. 281-290. https://doi.org/10.1196/annals.1402.018
Bonewald L. Osteocytes as dynamic multifunctional cells. In Skeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling. Vol. 1116. 2007. p. 281-290. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1402.018
Bonewald, Lynda. / Osteocytes as dynamic multifunctional cells. Skeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling. Vol. 1116 2007. pp. 281-290 (Annals of the New York Academy of Sciences).
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