Osteocytes: The master cells in bone remodelling

Matthew Prideaux, David M. Findlay, Gerald J. Atkins

Research output: Contribution to journalReview article

78 Scopus citations

Abstract

Bone remodelling is an essential process for shaping and maintaining bone mass in the mature skeleton. During our lifetime bone is constantly being removed by osteoclasts and new bone is formed by osteoblasts. The activities of osteoclasts and osteoblasts must be regulated under a strict balance to ensure that bone homeostasis is maintained. Osteocytes, which form an extensive, multi-functional syncytium throughout the bone, are increasingly considered to be the cells that maintain this balance. Current research is elucidating key signalling pathways by which the osteocyte exerts control over the other cell types in bone and over its own activities, and potential ways in which these pathways may be exploited therapeutically.

Original languageEnglish (US)
Pages (from-to)24-30
Number of pages7
JournalCurrent Opinion in Pharmacology
Volume28
DOIs
StatePublished - Jun 1 2016

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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