Osteoporosis in end-stage renal disease

J. S. Lindberg, Sharon Moe

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Maintaining the intricate bone mineral homeostasis in patients with chronic renal failure and renal osteodystrophy is a complex and challenging process. In addition to the well described high-turnover bone disease caused by secondary hyperparathyroidism and low-turnover disease in the form of osteomalacia (either from aluminum or a dynamic bone disease) osteopenia also is present in end-stage renal disease patients. In contrast to abnormalities in the ability of bone to remodel, osteopenia is a deficiency in bone mass or volume. The prevalence of fractures in dialysis patients, regardless of histomorphometry appears to exceed that observed in elderly women. This osteopenia that occurs in chronic renal failure patients secondary to multiple factors that include hypogonadism, medications (such as corticosteroids), immobilization, and the typical osteopenia associated with aging. All of these factors amplify the risk of fracture in dialysis patients.

Original languageEnglish (US)
Pages (from-to)115-122
Number of pages8
JournalSeminars in Nephrology
Volume19
Issue number2
StatePublished - 1999

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Metabolic Bone Diseases
Osteoporosis
Chronic Kidney Failure
Bone Diseases
Bone and Bones
Dialysis
Chronic Kidney Disease-Mineral and Bone Disorder
Osteomalacia
Secondary Hyperparathyroidism
Hypogonadism
Aluminum
Immobilization
Minerals
Adrenal Cortex Hormones
Homeostasis

ASJC Scopus subject areas

  • Nephrology

Cite this

Osteoporosis in end-stage renal disease. / Lindberg, J. S.; Moe, Sharon.

In: Seminars in Nephrology, Vol. 19, No. 2, 1999, p. 115-122.

Research output: Contribution to journalArticle

Lindberg, JS & Moe, S 1999, 'Osteoporosis in end-stage renal disease', Seminars in Nephrology, vol. 19, no. 2, pp. 115-122.
Lindberg, J. S. ; Moe, Sharon. / Osteoporosis in end-stage renal disease. In: Seminars in Nephrology. 1999 ; Vol. 19, No. 2. pp. 115-122.
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