Other tests in glaucoma: Optic nerve blood flow II

Alon Harris, Ehud Rechtman, Nisha S. Kheradiya, Rita Ehrlich

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

One-third of patients with primary OAG have normal intraocular pressures (IOPs) at the time of glaucoma diagnosis. This suggests that other risk factors, such as vascular changes, contribute to the pathogenesis of glaucomatous optic neuropathy [1, 2]. Recent population-based studies, including the Barbados Eye Study, Proyecto VER (vision evaluation and research), Baltimore Eye Survey, and Egna-Neumarkt Glaucoma Study, have shown that reduced ocular perfusion pressure, and most often diastolic perfusion pressure, is a significant risk factor for the prevalence and incidence of OAG [3-6]. The Early Manifest Glaucoma Trial (EMGT) recently found that lower systolic perfusion pressure, lower systolic blood pressure, and cardiovascular disease history are new predictors for glaucoma progression, strengthening the evidence for the role of vasculopathy in glaucoma [7]. Nevertheless, the role of ocular blood flow in glaucoma is controversial. A debate remains regarding whether blood flow abnormalities can lead to OAG primarily, if elevated IOP can secondarily damage the vasculature, or if the combination of vascular dysregulation and increased IOP causes OAG.

Original languageEnglish
Title of host publicationPearls of Glaucoma Management
PublisherSpringer Berlin Heidelberg
Pages165-173
Number of pages9
ISBN (Print)9783540682387
DOIs
StatePublished - 2010

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Optic Nerve
Glaucoma
Intraocular Pressure
Blood Pressure
Perfusion
Blood Vessels
Barbados
Optic Nerve Diseases
Baltimore
Hematologic Diseases
Cardiovascular Diseases
Pressure
Incidence
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Harris, A., Rechtman, E., Kheradiya, N. S., & Ehrlich, R. (2010). Other tests in glaucoma: Optic nerve blood flow II. In Pearls of Glaucoma Management (pp. 165-173). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-68240-0_20

Other tests in glaucoma : Optic nerve blood flow II. / Harris, Alon; Rechtman, Ehud; Kheradiya, Nisha S.; Ehrlich, Rita.

Pearls of Glaucoma Management. Springer Berlin Heidelberg, 2010. p. 165-173.

Research output: Chapter in Book/Report/Conference proceedingChapter

Harris, A, Rechtman, E, Kheradiya, NS & Ehrlich, R 2010, Other tests in glaucoma: Optic nerve blood flow II. in Pearls of Glaucoma Management. Springer Berlin Heidelberg, pp. 165-173. https://doi.org/10.1007/978-3-540-68240-0_20
Harris A, Rechtman E, Kheradiya NS, Ehrlich R. Other tests in glaucoma: Optic nerve blood flow II. In Pearls of Glaucoma Management. Springer Berlin Heidelberg. 2010. p. 165-173 https://doi.org/10.1007/978-3-540-68240-0_20
Harris, Alon ; Rechtman, Ehud ; Kheradiya, Nisha S. ; Ehrlich, Rita. / Other tests in glaucoma : Optic nerve blood flow II. Pearls of Glaucoma Management. Springer Berlin Heidelberg, 2010. pp. 165-173
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