Outcome of early hepatic portoenterostomy for biliary atresia

D. Volpert, F. White, M. J. Finegold, Jean Molleston, M. DeBaun, D. H. Perlmutter

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: The outcome of the hepatic portoenterostomy (Kasai) procedure for biliary atresia is improved when it is performed before 90 days of age. However, it is not known whether intervention before 30 days is better than intervention between 30 and 90 days. Methods: The authors reviewed the records of all patients seen by the Pediatric Gastroenterology Service at St. Louis Children's Hospital from 1984-1999 to ascertain the outcome of patients who underwent Kasai procedure before or after 30 days of age. Results: Of 92 patients with biliary atresia treated at St. Louis Children's Hospital over 15 years, 9 underwent the Kasai procedure before 30 days of age. Liver transplantation was necessary in 77.8% of these patients at a mean age of 11.0 ± 4.26 months, as compared with 53.4% at 32.14 ± 7.14 months for the remainder of the patients who underwent the procedure after 30 days of age. Conclusions: Although these data suggest that outcomes are worse for patients who undergo the procedure before 30 days of age, they may reflect a difference in the pathogenesis of biliary atresia that brings it to clinical attention earlier and may provide further evidence that biliary atresia is a phenotype for a number of distinct underlying disease processes.

Original languageEnglish (US)
Pages (from-to)265-269
Number of pages5
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume32
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Hepatic Portoenterostomy
Biliary Atresia
abnormal development
liver
liver transplant
Gastroenterology
Liver Transplantation
pathogenesis
Pediatrics
Phenotype
phenotype

Keywords

  • Biliary atresia
  • Ductal plate malformation
  • Hepatic portoenterostomy
  • Neonatal jaundice

ASJC Scopus subject areas

  • Gastroenterology
  • Histology
  • Medicine (miscellaneous)
  • Food Science
  • Pediatrics, Perinatology, and Child Health

Cite this

Outcome of early hepatic portoenterostomy for biliary atresia. / Volpert, D.; White, F.; Finegold, M. J.; Molleston, Jean; DeBaun, M.; Perlmutter, D. H.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 32, No. 3, 2001, p. 265-269.

Research output: Contribution to journalArticle

Volpert, D. ; White, F. ; Finegold, M. J. ; Molleston, Jean ; DeBaun, M. ; Perlmutter, D. H. / Outcome of early hepatic portoenterostomy for biliary atresia. In: Journal of Pediatric Gastroenterology and Nutrition. 2001 ; Vol. 32, No. 3. pp. 265-269.
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