Outcomes after radical prostatectomy in men receiving previous pelvic radiation for non-prostate malignancies

Timothy Masterson, Alexei Wedmid, Jaspreet S. Sandhu, James A. Eastham

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: To report the perioperative and functional outcomes of nine patients treated at our institution who had radical prostatectomy (RP) after previous pelvic radiotherapy (RT) for non-prostate malignancies. Patients and Methods: From 1993 to 2007, nine patients had RP after external beam RT for testicular seminoma (six), anorectal cancer (two) and colon cancer (one). Clinical information was obtained from a prospective prostate cancer database. Results: RP was completed with no identifiable injury to adjacent structures in all nine patients. Four patients had significant pelvic fibrosis, and three required bilateral neurovascular bundle (NVB) resection. The NVB was preserved in the remaining six patients, four with good preoperative erectile function. However, no patient recovered erectile function after RP at a median (range) follow-up of 75 (12-172) months. Of seven men continent before RP, four required one or fewer pads daily and three were completely dry, achieving complete urinary control at a median (range) time of 7.5 (2-20) months. Two patients developed an anastomotic stricture, one being associated with concomitant ureteric stricture. Conclusions: RP after pelvic RT for non-prostate malignancies was not associated with increased intraoperative morbidity. However, rates of anastomotic stricture, erectile dysfunction and urinary incontinence appeared to be higher than those reported after RP in men with no previous RT, and comparable with those seen in the salvage RP setting. copyright

Original languageEnglish (US)
Pages (from-to)482-485
Number of pages4
JournalBJU International
Volume104
Issue number4
DOIs
StatePublished - Aug 2009
Externally publishedYes

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Prostatectomy
Radiation
Neoplasms
Radiotherapy
Pathologic Constriction
Colonic Neoplasms
Seminoma
Urinary Incontinence
Erectile Dysfunction
Prostatic Neoplasms
Fibrosis
Databases
Morbidity
Wounds and Injuries

Keywords

  • Cancer
  • Perioperative complications
  • Prostate
  • Radical prostatectomy
  • Radiotherapy

ASJC Scopus subject areas

  • Urology

Cite this

Outcomes after radical prostatectomy in men receiving previous pelvic radiation for non-prostate malignancies. / Masterson, Timothy; Wedmid, Alexei; Sandhu, Jaspreet S.; Eastham, James A.

In: BJU International, Vol. 104, No. 4, 08.2009, p. 482-485.

Research output: Contribution to journalArticle

Masterson, Timothy ; Wedmid, Alexei ; Sandhu, Jaspreet S. ; Eastham, James A. / Outcomes after radical prostatectomy in men receiving previous pelvic radiation for non-prostate malignancies. In: BJU International. 2009 ; Vol. 104, No. 4. pp. 482-485.
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