Outcomes and predictors of benign histology in patients undergoing robotic partial or radical nephrectomy for renal masses: A multicenter study

Naveen Nandanan, Alessandro Veccia, Alessandro Antonelli, Ithaar Derweesh, Alexandre Mottrie, Andrea Minervini, Monish Aron, Giuseppe Simone, Umberto Capitanio, Claudio Simeone, Daniel Eun, Sisto Perdonà, James Porter, Chandru Sundaram, Chao Zhang, Robert Uzzo, Ben Challacombe, Lance J. Hampton, Jihad Kaouk, Francesco PorpigliaRiccardo Autorino

Research output: Contribution to journalArticle

Abstract

Introduction Theaim of this study was to assess preoperative factors associated with benign histology in patients undergoing surgical removal of a renal mass and to analyze outcomes of robotic partial nephrectomy (PN) and radical nephrectomy (RN) for these masses. Material and methods Overall, 2,944 cases (543 benign and 2,401 malignant) who underwent robotic PN and RN between 2003–2018 at 10 institutions worldwide were included. The assessment of the predictors of benign histology was made at the final surgical pathology report. Descriptive statistics, Mann-Whitney U, Pearson’s χ2, and logistic regression analysis were used. Results Patients in the benign group were mostly female (61 vs. 33%; p <0.001), with lower body mass index (BMI) (26.0 vs. 27.1 kg/m2; p <0.001). The benign group presented smaller tumor size (2.8 vs. 3.5 cm; p <0.001), R.E.N.A.L. score (6.0 vs. 7.0; p <0.001). There was a lower rate of hilar (11 vs.18%; p = 0.001), cT≥3 (1 vs. 4.5%; p <0.001) tumors in the benign group. There was a statistically significant higher rate of PN in the benign group (97 vs. 86%; p <0.001) as well as a statistically significant lower 30-day re-admission rate (2 vs. 5%; p = 0.081). Multivariable analysis showed male gender (OR: 0.52; p <0.001), BMI (OR: 0.95; p <0.001), and cT3a (OR: 0.22; p = 0.005) to be inversely associated to benign histology. Conclusions In 18% of cases, a benign histologic type was found. Only 3% of these tumors were treated with RN. Female gender, lower BMI, and higher T staging showed to be independent predictors of benign histology.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalCentral European Journal of Urology
Volume73
Issue number1
DOIs
StatePublished - 2020
Externally publishedYes

Keywords

  • Benign renal masses
  • Malignant renal masses
  • Predictors
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Urology

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  • Cite this

    Nandanan, N., Veccia, A., Antonelli, A., Derweesh, I., Mottrie, A., Minervini, A., Aron, M., Simone, G., Capitanio, U., Simeone, C., Eun, D., Perdonà, S., Porter, J., Sundaram, C., Zhang, C., Uzzo, R., Challacombe, B., Hampton, L. J., Kaouk, J., ... Autorino, R. (2020). Outcomes and predictors of benign histology in patients undergoing robotic partial or radical nephrectomy for renal masses: A multicenter study. Central European Journal of Urology, 73(1), 33-38. https://doi.org/10.5173/ceju.2020.0019