Outcomes for Soft-Tissue Sarcoma in 8249 Cases from a Large State Cancer Registry

Juan C. Gutierrez, Eduardo A. Perez, Dido Franceschi, Frederick L. Moffat, Alan S. Livingstone, Leonidas Koniaris

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Background and objectives: To date, outcome reports for soft-tissue sarcoma (STS) have largely been limited to single or paired institutional series. To more accurately elucidate population-based outcomes and prognostic factors associated with STS, a large cancer registry was examined. Methods: STS arising in the Florida Cancer Data System were examined (1981-2004). Results: A total of 8249 patients were identified, the calculated annual incidence of sarcoma being approximately 38 cases per million in 2003. The tumor histologies among these patients were leiomyosarcoma and gastrointestinal stromal tumor (LMS/GIST) (43.5%), malignant fibrous histiocytoma (MFH) (31.5%), liposarcoma (19.0%), and fibrosarcoma (6.0%). Tumors were situated in the extremities (30.7%), truncal or visceral locations (50.4%), retroperitoneum (11.7%), and head or neck (7.2%). Thirty-three percent of lesions were over 10 cm in greatest dimension, while 50.2% were classified as high grade. Median overall survival was 25 months. Superior survival was observed for liposarcomas and fibrosarcomas as compared to MFH and LMS/GIST (P <0.001). Retroperitoneal and truncal sarcomas had a more ominous prognosis than did other sites (P <0.001). Multivariate analysis of pretreatment variables demonstrated that increasing age, male gender, non-Caucasian race, advanced stage, and a truncal or retroperitoneal location were each independently associated with lower survival. Histological subtype was also an independent predictor of outcome. Surgical resection and radiation therapy were the only treatment variables shown to improve survival. Conclusions: Histological subtype, tumor site, and stage are independent prognostic factors in STS. Surgical resection and radiotherapy are unique among treatment modalities in association with a significant survival benefit.

Original languageEnglish (US)
Pages (from-to)105-114
Number of pages10
JournalJournal of Surgical Research
Volume141
Issue number1
DOIs
StatePublished - Jul 2007
Externally publishedYes

Fingerprint

Sarcoma
Registries
Survival
Malignant Fibrous Histiocytoma
Liposarcoma
Neoplasms
Gastrointestinal Stromal Tumors
Leiomyosarcoma
Fibrosarcoma
Radiotherapy
Information Systems
Histology
Neck
Multivariate Analysis
Extremities
Head
Incidence
Therapeutics
Population

Keywords

  • chemotherapy
  • histological subtypes
  • prognostic factors
  • radiotherapy
  • soft-tissue sarcoma
  • surgery

ASJC Scopus subject areas

  • Surgery

Cite this

Gutierrez, J. C., Perez, E. A., Franceschi, D., Moffat, F. L., Livingstone, A. S., & Koniaris, L. (2007). Outcomes for Soft-Tissue Sarcoma in 8249 Cases from a Large State Cancer Registry. Journal of Surgical Research, 141(1), 105-114. https://doi.org/10.1016/j.jss.2007.02.026

Outcomes for Soft-Tissue Sarcoma in 8249 Cases from a Large State Cancer Registry. / Gutierrez, Juan C.; Perez, Eduardo A.; Franceschi, Dido; Moffat, Frederick L.; Livingstone, Alan S.; Koniaris, Leonidas.

In: Journal of Surgical Research, Vol. 141, No. 1, 07.2007, p. 105-114.

Research output: Contribution to journalArticle

Gutierrez, JC, Perez, EA, Franceschi, D, Moffat, FL, Livingstone, AS & Koniaris, L 2007, 'Outcomes for Soft-Tissue Sarcoma in 8249 Cases from a Large State Cancer Registry', Journal of Surgical Research, vol. 141, no. 1, pp. 105-114. https://doi.org/10.1016/j.jss.2007.02.026
Gutierrez, Juan C. ; Perez, Eduardo A. ; Franceschi, Dido ; Moffat, Frederick L. ; Livingstone, Alan S. ; Koniaris, Leonidas. / Outcomes for Soft-Tissue Sarcoma in 8249 Cases from a Large State Cancer Registry. In: Journal of Surgical Research. 2007 ; Vol. 141, No. 1. pp. 105-114.
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