Outcomes of Unilateral Cataracts in Infants and Toddlers 7 to 24 Months of Age: Toddler Aphakia and Pseudophakia Study (TAPS)

Toddler Aphakia and Pseudophakia Study Group (TAPS)

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To evaluate outcomes of unilateral cataract surgery in children 7 to 24 months of age. Design: Retrospective case series at 10 Infant Aphakia Treatment Study (IATS) sites. Participants: The Toddler Aphakia and Pseudophakia Study is a registry of children treated by surgeons who participated in the IATS. Methods: Children underwent unilateral cataract surgery with or without intraocular lens (IOL) placement during the IATS enrollment years of 2004 and 2010. Main Outcome Measures: Intraoperative complications, adverse events (AEs), visual acuity, and strabismus. Results: Fifty-six children were included with a mean postoperative follow-up of 47.6 months. Median age at cataract surgery was 13.9 months (range, 7.2–22.9). Ninety-two percent received a primary IOL. Intraoperative complications occurred in 4 patients (7%). At 5 years of age, visual acuity of treated eyes was very good (≥20/40) in 11% and poor (≤20/200) in 44%. Adverse events were identified in 24%, with a 4% incidence of glaucoma suspect. An additional unplanned intraocular surgery occurred in 14% of children. Neither AEs nor intraocular reoperations were more common for children with surgery at 7 to 12 months of age than for those who underwent surgery at 13 to 24 months of age (AE rate, 21% vs. 25% [P = 0.60]; reoperation rate, 13% vs. 16% [P = 1.00]). Conclusions: Although most children underwent IOL implantation concurrent with unilateral cataract removal, the incidence of complications, reoperations, and glaucoma was low when surgery was performed between 7 and 24 months of age and compared favorably with same-site IATS data for infants undergoing surgery before 7 months of age. Our study showed that IOL implantation is relatively safe in children older than 6 months and younger than 2 years.

Original languageEnglish (US)
Pages (from-to)1189-1195
Number of pages7
JournalOphthalmology
Volume126
Issue number8
DOIs
StatePublished - Aug 1 2019

Fingerprint

Pseudophakia
Aphakia
Cataract
Reoperation
Intraocular Lens Implantation
Intraocular Lenses
Intraoperative Complications
Visual Acuity
Ocular Hypertension
Strabismus
Incidence
Therapeutics
Glaucoma
Registries
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Outcomes of Unilateral Cataracts in Infants and Toddlers 7 to 24 Months of Age : Toddler Aphakia and Pseudophakia Study (TAPS). / Toddler Aphakia and Pseudophakia Study Group (TAPS).

In: Ophthalmology, Vol. 126, No. 8, 01.08.2019, p. 1189-1195.

Research output: Contribution to journalArticle

Toddler Aphakia and Pseudophakia Study Group (TAPS). / Outcomes of Unilateral Cataracts in Infants and Toddlers 7 to 24 Months of Age : Toddler Aphakia and Pseudophakia Study (TAPS). In: Ophthalmology. 2019 ; Vol. 126, No. 8. pp. 1189-1195.
@article{9491d8ec2fc142b996ac1105c4dd0751,
title = "Outcomes of Unilateral Cataracts in Infants and Toddlers 7 to 24 Months of Age: Toddler Aphakia and Pseudophakia Study (TAPS)",
abstract = "Purpose: To evaluate outcomes of unilateral cataract surgery in children 7 to 24 months of age. Design: Retrospective case series at 10 Infant Aphakia Treatment Study (IATS) sites. Participants: The Toddler Aphakia and Pseudophakia Study is a registry of children treated by surgeons who participated in the IATS. Methods: Children underwent unilateral cataract surgery with or without intraocular lens (IOL) placement during the IATS enrollment years of 2004 and 2010. Main Outcome Measures: Intraoperative complications, adverse events (AEs), visual acuity, and strabismus. Results: Fifty-six children were included with a mean postoperative follow-up of 47.6 months. Median age at cataract surgery was 13.9 months (range, 7.2–22.9). Ninety-two percent received a primary IOL. Intraoperative complications occurred in 4 patients (7{\%}). At 5 years of age, visual acuity of treated eyes was very good (≥20/40) in 11{\%} and poor (≤20/200) in 44{\%}. Adverse events were identified in 24{\%}, with a 4{\%} incidence of glaucoma suspect. An additional unplanned intraocular surgery occurred in 14{\%} of children. Neither AEs nor intraocular reoperations were more common for children with surgery at 7 to 12 months of age than for those who underwent surgery at 13 to 24 months of age (AE rate, 21{\%} vs. 25{\%} [P = 0.60]; reoperation rate, 13{\%} vs. 16{\%} [P = 1.00]). Conclusions: Although most children underwent IOL implantation concurrent with unilateral cataract removal, the incidence of complications, reoperations, and glaucoma was low when surgery was performed between 7 and 24 months of age and compared favorably with same-site IATS data for infants undergoing surgery before 7 months of age. Our study showed that IOL implantation is relatively safe in children older than 6 months and younger than 2 years.",
author = "{Toddler Aphakia and Pseudophakia Study Group (TAPS)} and Bothun, {Erick D.} and Wilson, {M. Edward} and Traboulsi, {Elias I.} and Diehl, {Nancy N.} and Plager, {David A.} and Vanderveen, {Deborah K.} and Freedman, {Sharon F.} and Yen, {Kimberly G.} and Weil, {Natalie C.} and Loh, {Allison R.} and David Morrison and Anderson, {Jill S.} and Lambert, {Scott R.} and Scott Lambert and Amy Hutchinson and Stephen Christiansen and Erick Bothun and Ed Wilson and Elias Traboulsi and David Plager and Daniel Neely and Deborah Vanderveen and Ed Buckley and Sharon Freedman and Wallace, {David K.} and Kimberly Yen and David Wheeler",
year = "2019",
month = "8",
day = "1",
doi = "10.1016/j.ophtha.2019.03.011",
language = "English (US)",
volume = "126",
pages = "1189--1195",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "8",

}

TY - JOUR

T1 - Outcomes of Unilateral Cataracts in Infants and Toddlers 7 to 24 Months of Age

T2 - Toddler Aphakia and Pseudophakia Study (TAPS)

AU - Toddler Aphakia and Pseudophakia Study Group (TAPS)

AU - Bothun, Erick D.

AU - Wilson, M. Edward

AU - Traboulsi, Elias I.

AU - Diehl, Nancy N.

AU - Plager, David A.

AU - Vanderveen, Deborah K.

AU - Freedman, Sharon F.

AU - Yen, Kimberly G.

AU - Weil, Natalie C.

AU - Loh, Allison R.

AU - Morrison, David

AU - Anderson, Jill S.

AU - Lambert, Scott R.

AU - Lambert, Scott

AU - Hutchinson, Amy

AU - Christiansen, Stephen

AU - Bothun, Erick

AU - Wilson, Ed

AU - Traboulsi, Elias

AU - Plager, David

AU - Neely, Daniel

AU - Vanderveen, Deborah

AU - Buckley, Ed

AU - Freedman, Sharon

AU - Wallace, David K.

AU - Yen, Kimberly

AU - Wheeler, David

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Purpose: To evaluate outcomes of unilateral cataract surgery in children 7 to 24 months of age. Design: Retrospective case series at 10 Infant Aphakia Treatment Study (IATS) sites. Participants: The Toddler Aphakia and Pseudophakia Study is a registry of children treated by surgeons who participated in the IATS. Methods: Children underwent unilateral cataract surgery with or without intraocular lens (IOL) placement during the IATS enrollment years of 2004 and 2010. Main Outcome Measures: Intraoperative complications, adverse events (AEs), visual acuity, and strabismus. Results: Fifty-six children were included with a mean postoperative follow-up of 47.6 months. Median age at cataract surgery was 13.9 months (range, 7.2–22.9). Ninety-two percent received a primary IOL. Intraoperative complications occurred in 4 patients (7%). At 5 years of age, visual acuity of treated eyes was very good (≥20/40) in 11% and poor (≤20/200) in 44%. Adverse events were identified in 24%, with a 4% incidence of glaucoma suspect. An additional unplanned intraocular surgery occurred in 14% of children. Neither AEs nor intraocular reoperations were more common for children with surgery at 7 to 12 months of age than for those who underwent surgery at 13 to 24 months of age (AE rate, 21% vs. 25% [P = 0.60]; reoperation rate, 13% vs. 16% [P = 1.00]). Conclusions: Although most children underwent IOL implantation concurrent with unilateral cataract removal, the incidence of complications, reoperations, and glaucoma was low when surgery was performed between 7 and 24 months of age and compared favorably with same-site IATS data for infants undergoing surgery before 7 months of age. Our study showed that IOL implantation is relatively safe in children older than 6 months and younger than 2 years.

AB - Purpose: To evaluate outcomes of unilateral cataract surgery in children 7 to 24 months of age. Design: Retrospective case series at 10 Infant Aphakia Treatment Study (IATS) sites. Participants: The Toddler Aphakia and Pseudophakia Study is a registry of children treated by surgeons who participated in the IATS. Methods: Children underwent unilateral cataract surgery with or without intraocular lens (IOL) placement during the IATS enrollment years of 2004 and 2010. Main Outcome Measures: Intraoperative complications, adverse events (AEs), visual acuity, and strabismus. Results: Fifty-six children were included with a mean postoperative follow-up of 47.6 months. Median age at cataract surgery was 13.9 months (range, 7.2–22.9). Ninety-two percent received a primary IOL. Intraoperative complications occurred in 4 patients (7%). At 5 years of age, visual acuity of treated eyes was very good (≥20/40) in 11% and poor (≤20/200) in 44%. Adverse events were identified in 24%, with a 4% incidence of glaucoma suspect. An additional unplanned intraocular surgery occurred in 14% of children. Neither AEs nor intraocular reoperations were more common for children with surgery at 7 to 12 months of age than for those who underwent surgery at 13 to 24 months of age (AE rate, 21% vs. 25% [P = 0.60]; reoperation rate, 13% vs. 16% [P = 1.00]). Conclusions: Although most children underwent IOL implantation concurrent with unilateral cataract removal, the incidence of complications, reoperations, and glaucoma was low when surgery was performed between 7 and 24 months of age and compared favorably with same-site IATS data for infants undergoing surgery before 7 months of age. Our study showed that IOL implantation is relatively safe in children older than 6 months and younger than 2 years.

UR - http://www.scopus.com/inward/record.url?scp=85065047925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065047925&partnerID=8YFLogxK

U2 - 10.1016/j.ophtha.2019.03.011

DO - 10.1016/j.ophtha.2019.03.011

M3 - Article

C2 - 30880109

AN - SCOPUS:85065047925

VL - 126

SP - 1189

EP - 1195

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 8

ER -