Ovarian cancer stem cells: Role in metastasis and opportunity for therapeutic targeting

Xingyue Zong, Kenneth P. Nephew

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage. Cancer stem cells (CSCs) that exist within the bulk tumor survive first-line chemotherapy and contribute to resistant disease with metastasis. Understanding the key features of CSC biology provides valuable opportunities to develop OCSC-directed therapeutics, which will eventually improve the clinical outcomes of patients. Although significant developments have occurred since OCSCs were first described, the involvement of CSCs in ovarian tumor metastasis is not fully understood. Here, we discuss putative CSC markers and the fundamental role of CSCs in facilitating tumor dissemination in OC. Additionally, we focus on promising CSC-targeting strategies in preclinical and clinical studies of OC and discuss potential challenges in CSC research.

Original languageEnglish (US)
Article number934
JournalCancers
Volume11
Issue number7
DOIs
StatePublished - Jul 2019

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Keywords

  • Cancer stem cells
  • Metastasis
  • Ovarian cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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