Overdiagnosis of bladder carcinoma

Liang Cheng, David G. Bostwick

Research output: Contribution to journalArticle

14 Scopus citations


OBJECTIVE: To describe a group of archival patients who were overdiagnosed with bladder cancer according to contemporary criteria. STUDY DESIGN: The study group consisted of 27 overdiagnosed patients who were identified upon review of a consecutive series of well-differentiated urothelial carcinomas (grade 1 transitional cell carcinoma) diagnosed between 1958 and 1963. RESULTS: The mean patient age was 61 years (range, 34-83). Findings overdiagnosed as malignancy included urothelial papilloma (9 patients), inverted papilloma (5), exuberant von Brunn's nest proliferation (hyperplasia) (5), papillary and polypoid cystitis (4), papillary urothelial hyperplasia (2), squamous papilloma (1) and endocervicosis (1). None were treated. During a mean followup of 12.2 years, 1 patient developed carcinoma in situ 11 years after diagnosis, and 1 was diagnosed with noninvasive low-grade urothelial carcinoma 5 years after diagnosis. CONCLUSION: The most frequent mimics of malignancy were urothelial papilloma, inverted papilloma, von Brunn nest hyperplasia and papillary polypoid cystitis. Awareness of these cancer mimics is critical to avoid overdiagnosis of bladder cancer.

Original languageEnglish (US)
Pages (from-to)261-264
Number of pages4
JournalAnalytical and Quantitative Cytology and Histology
Issue number5
StatePublished - Oct 1 2008


  • Bladder cancer
  • Overdiagnosis
  • Urinary bladder

ASJC Scopus subject areas

  • Anatomy
  • Histology

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