Overexpression of platelet-derived growth factor (PDGF) B chain and type β PDGF receptor in human chronic pancreatitis

Matthias Ebert, Hans Udo Kasper, Sara Hernberg, Helmut Friess, Markus W. Büchler, Albert Roessner, Murray Korc, Peter Malfertheiner

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Platelet-derived growth factors (PDGF) are mitogenic polypeptides that are involved in cellular proliferation and tissue repair. The expression of PDGFs and type β PDGF receptor was examined in the normal human pancreas and in chronic pancreatitis, a fibrotic disease associated with fibroblastic proliferation, atrophy, and acinar cell dedifferentiation. In the normal human pancreas, PDGF A chain mRNA levels were relatively abundant, whereas PDGF B chain mRNA levels were not detected, and type β PDGF receptor mRNA transcripts were present at low levels. In the normal pancreas, PDGF immunoreactivity was present in islet cells, whereas type β PDGF receptor immunoreactivity was present in acinar cells. In chronic pancreatitis, PDGF A chain mRNA transcripts were also abundant, and 11 of 19 samples exhibited the PDGF B chain mRNA transcript. In addition, there was a significant increase in the mRNA levels of type β PDGF receptor in the pancreatitis samples by comparison with the normal pancreas (P < 0.001). In chronic pancreatitis tissues, PDGF and type β PDGF receptor immunoreactivity were present in acinar, ductal, islet, and endothelial cells, fibroblasts, and leukocytes. The concomitant overexpression of PDGFs and of the type β PDGF receptor points to the existence of autocrine and paracrine PDGF-dependent loops in human chronic pancreatitis.

Original languageEnglish (US)
Pages (from-to)567-574
Number of pages8
JournalDigestive diseases and sciences
Volume43
Issue number3
DOIs
StatePublished - Apr 18 1998

Keywords

  • Chronic pancreatitis
  • Expression
  • Platelet-derived growth factor

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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