Oxidative stress impairs endothelial progenitor cell function

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Circulating endothelial progenitor cells (EPCs) in adult human peripheral blood were identified in 1997. Since their original identification, EPCs have been extensively studied as biomarkers to assess the risk of cardiovascular disease in human subjects and as a potential cell therapeutic for vascular regeneration. EPCs are exposed to oxidative stress during vascular injury as residents of blood vessel walls or as circulating cells homing to sites of neovascularization. Given the links between oxidative injury, endothelial cell dysfunction, and vascular disease, recent investigation has focused on the responses of EPCs to oxidant stress and the molecular mechanisms that control redox regulation in these specialized cells. In this review, we discuss the various cell and flow-cytometric techniques used to define and isolate EPCs from circulating blood and the current human and mouse genetic data, which offer insights into redox control in EPC biology and angiogenesis. Finally, we review how EPC responses to oxidant stress may be a critical determinant in maintaining the integrity and function of the cardiovascular system and how perturbations of redox control in EPCs may lead to various human diseases.

Original languageEnglish
Pages (from-to)1895-1907
Number of pages13
JournalAntioxidants and Redox Signaling
Volume10
Issue number11
DOIs
StatePublished - Nov 1 2008

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Oxidative stress
Endothelial cells
Oxidative Stress
Oxidation-Reduction
Oxidants
Blood Vessels
Blood
Cytology
Endothelial Progenitor Cells
Cardiovascular system
Vascular System Injuries
Medical Genetics
Cardiovascular System
Vascular Diseases
Blood vessels
Biomarkers
Cell Biology
Regeneration
Cardiovascular Diseases
Endothelial Cells

ASJC Scopus subject areas

  • Biochemistry

Cite this

Oxidative stress impairs endothelial progenitor cell function. / Case, Jamie; Ingram, David; Haneline, Laura.

In: Antioxidants and Redox Signaling, Vol. 10, No. 11, 01.11.2008, p. 1895-1907.

Research output: Contribution to journalArticle

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