Oxidative stress in diabetes: A mechanistic overview of its effects on atherogenesis and myocardial dysfunction

Jawahar L. Mehta, Neda Rasouli, Anjan K. Sinha, Behzad Molavi

Research output: Contribution to journalReview article

124 Scopus citations

Abstract

Diabetes is a major risk factor for atherosclerosis. Atherogenesis involves endothelial dysfunction, activation and injury, inflammation, and smooth muscle cell migration and proliferation. Platelet activation in the narrowed arteries is the most proximate event in the culmination of an acute event such as acute myocardial infraction and stroke. Hyperglycemia is associated with all these adverse events in the process of genesis of atherosclerosis. The effect of diabetes (hyperglycemia) is mediated in large part by the state of enhanced oxidative stress, which is not counter-balanced by endogenous antioxidants. This paper reviews the ignition of oxidative stress in diabetes and the mediation of events leading to atherogenesis.

Original languageEnglish (US)
Pages (from-to)794-803
Number of pages10
JournalInternational Journal of Biochemistry and Cell Biology
Volume38
Issue number5-6
DOIs
StatePublished - Mar 16 2006
Externally publishedYes

Keywords

  • Atherosclerosis
  • Diabetes
  • Oxidative stress
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Fingerprint Dive into the research topics of 'Oxidative stress in diabetes: A mechanistic overview of its effects on atherogenesis and myocardial dysfunction'. Together they form a unique fingerprint.

  • Cite this