Oxidative stress in nonalcoholic fatty liver disease

Pathogenesis and antioxidant therapies

Samer Gawrieh, Emmanuel C. Opara, Timothy R. Koch

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Nonalcoholic fatty liver disease is a common cause of chronic liver disease, a common finding on liver biopsy in those patients with abnormal blood transaminase levels, and a common cause of cryptogenic cirrhosis in the United States. The prevalence of this disorder is expected to rise with the increase in obesity, and the clinical spectrum can range from simple steatosis (fatty liver) to cirrhosis of the liver. Insulin resistance is thought to be pivotal for the development of steatosis, and oxidative stress may be a potential factor that can promote hepatic necroinflammation and fibrosis. Preliminary studies have examined the role of oxidative stress and antioxidants in animal and human studies of this disorder. Efforts to improve the hepatic antioxidant system could be achieved by optimizing the patient's diet, by supplementation with precursors for antioxidants, or by supplementation with essential metals and/or antioxidants. Randomized, controlled trials are required to examine these potential approaches using patients with this disorder.

Original languageEnglish (US)
Pages (from-to)506-514
Number of pages9
JournalJournal of Investigative Medicine
Volume52
Issue number8
StatePublished - 2004
Externally publishedYes

Fingerprint

Oxidative stress
Liver
Oxidative Stress
Antioxidants
Fatty Liver
Therapeutics
Transaminases
Liver Cirrhosis
Biopsy
Insulin Resistance
Liver Diseases
Nutrition
Fibrosis
Chronic Disease
Randomized Controlled Trials
Obesity
Metals
Diet
Animals
Blood

Keywords

  • Antioxidant
  • Liver
  • Oxidative stress
  • Steatohepatitis

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Oxidative stress in nonalcoholic fatty liver disease : Pathogenesis and antioxidant therapies. / Gawrieh, Samer; Opara, Emmanuel C.; Koch, Timothy R.

In: Journal of Investigative Medicine, Vol. 52, No. 8, 2004, p. 506-514.

Research output: Contribution to journalReview article

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