Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects

Raymond Konger, Gopal K. Marathe, Yongxue Yao, Qiwei Zhang, Jeffrey Travers

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. Inasmuch as UVR is a known pro-oxidative stressor, one potential target for UVR could be oxidatively modified glycerophosphocholines (GPC). Importantly, recent studies demonstrate that these oxidized GPCs (ox-GPC) are potent agonists for the platelet-activating factor receptor and peroxisome proliferator-activated receptor gamma. This review discusses these new biologically active lipids and their down-stream receptor targets that provide a unique system of biosensors for detecting and responding to UVR photo-oxidation.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalProstaglandins and Other Lipid Mediators
Volume87
Issue number1-4
DOIs
StatePublished - Dec 2008

Fingerprint

Radiation effects
Radiation Effects
Ultraviolet Rays
Ultraviolet radiation
Radiation
Photooxidation
PPAR gamma
Biosensing Techniques
Biosensors
Skin
Lipids

Keywords

  • Glycerophosphoscholines
  • Oxidation
  • Peroxisome proliferator-activated receptor gamma
  • Platelet-activating factor receptor
  • Ultraviolet rays

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Cell Biology

Cite this

Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects. / Konger, Raymond; Marathe, Gopal K.; Yao, Yongxue; Zhang, Qiwei; Travers, Jeffrey.

In: Prostaglandins and Other Lipid Mediators, Vol. 87, No. 1-4, 12.2008, p. 1-8.

Research output: Contribution to journalArticle

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