Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects

Raymond L. Konger, Gopal K. Marathe, Yongxue Yao, Qiwei Zhang, Jeffrey B. Travers

Research output: Contribution to journalShort survey

25 Scopus citations

Abstract

Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. Inasmuch as UVR is a known pro-oxidative stressor, one potential target for UVR could be oxidatively modified glycerophosphocholines (GPC). Importantly, recent studies demonstrate that these oxidized GPCs (ox-GPC) are potent agonists for the platelet-activating factor receptor and peroxisome proliferator-activated receptor gamma. This review discusses these new biologically active lipids and their down-stream receptor targets that provide a unique system of biosensors for detecting and responding to UVR photo-oxidation.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalProstaglandins and Other Lipid Mediators
Volume87
Issue number1-4
DOIs
StatePublished - Dec 1 2008

    Fingerprint

Keywords

  • Glycerophosphoscholines
  • Oxidation
  • Peroxisome proliferator-activated receptor gamma
  • Platelet-activating factor receptor
  • Ultraviolet rays

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Cell Biology

Cite this