P-glycoprotein expression in non-Hodgkin's lymphoma

R. West, E. Boyle, David Grignon, I. Chin-Yee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Tissues from twenty-nine patients with non-Hodgkin's lymphoma (NHL) were examined for the presence of the P-glycoprotein (Pgp), a transmembrane protein associated with multidrug resistance. Six of the 29 NHL (21%) expressed Pgp; 3 of 8 (38%) low grade and 3 of 16 (19%) intermediate grade. No relationship was found between Pgp expression and age, stage, lactate dehydrogenase levels, extranodal disease or previous chemotherapy exposure. Pgp was present in 3 of 13 (23%) complete responders and 3 of 11 (27%) partial or nonresponders (p>0.10) suggesting no direct association between treatment response and Pgp expression in this series.

Original languageEnglish (US)
Pages (from-to)1237-1242
Number of pages6
JournalInternational Journal of Oncology
Volume4
Issue number6
StatePublished - 1994
Externally publishedYes

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P-Glycoprotein
Non-Hodgkin's Lymphoma
Multidrug Resistance-Associated Proteins
L-Lactate Dehydrogenase
Drug Therapy

Keywords

  • multidrug resistance
  • non-Hodgkin's lymphoma
  • P-glycoprotein and JSB-1 monoclonal antibody

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

West, R., Boyle, E., Grignon, D., & Chin-Yee, I. (1994). P-glycoprotein expression in non-Hodgkin's lymphoma. International Journal of Oncology, 4(6), 1237-1242.

P-glycoprotein expression in non-Hodgkin's lymphoma. / West, R.; Boyle, E.; Grignon, David; Chin-Yee, I.

In: International Journal of Oncology, Vol. 4, No. 6, 1994, p. 1237-1242.

Research output: Contribution to journalArticle

West, R, Boyle, E, Grignon, D & Chin-Yee, I 1994, 'P-glycoprotein expression in non-Hodgkin's lymphoma', International Journal of Oncology, vol. 4, no. 6, pp. 1237-1242.
West, R. ; Boyle, E. ; Grignon, David ; Chin-Yee, I. / P-glycoprotein expression in non-Hodgkin's lymphoma. In: International Journal of Oncology. 1994 ; Vol. 4, No. 6. pp. 1237-1242.
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