P-glycoprotein expression in non-Hodgkin's lymphoma

R. West, E. Boyle, D. Grignon, I. Chin-Yee

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Tissues from twenty-nine patients with non-Hodgkin's lymphoma (NHL) were examined for the presence of the P-glycoprotein (Pgp), a transmembrane protein associated with multidrug resistance. Six of the 29 NHL (21%) expressed Pgp; 3 of 8 (38%) low grade and 3 of 16 (19%) intermediate grade. No relationship was found between Pgp expression and age, stage, lactate dehydrogenase levels, extranodal disease or previous chemotherapy exposure. Pgp was present in 3 of 13 (23%) complete responders and 3 of 11 (27%) partial or nonresponders (p>0.10) suggesting no direct association between treatment response and Pgp expression in this series.

Original languageEnglish (US)
Pages (from-to)1237-1242
Number of pages6
JournalInternational journal of oncology
Volume4
Issue number6
StatePublished - Jan 1 1994

Keywords

  • P-glycoprotein and JSB-1 monoclonal antibody
  • multidrug resistance
  • non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'P-glycoprotein expression in non-Hodgkin's lymphoma'. Together they form a unique fingerprint.

  • Cite this

    West, R., Boyle, E., Grignon, D., & Chin-Yee, I. (1994). P-glycoprotein expression in non-Hodgkin's lymphoma. International journal of oncology, 4(6), 1237-1242.