P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1

Ingolf Bach, Simon J. Rhodes, Richard V. Pearse, Thorsten Heinzel, Bernd Gloss, Kathleen M. Scully, Paul E. Sawchenko, Michael G. Rosenfeld

Research output: Contribution to journalArticle

283 Scopus citations

Abstract

A pituitary LIM homeodomain factor, P-Lim, is expressed as Rathke's pouch forms and as specific pituitary cell phenotypes are established, suggesting functional roles throughout pituitary development. While selectively expressed in both anterior and intermediate pituitary in mature mice, P-Lim is also transiently expressed in the developing ventral neural cord and brainstem. P-Lim binds to and activates the promoter of the α-glycoprotein subunit gene, a marker of early pituitary development, and synergizes with Pit-1 in transcriptional activation of genes encoding terminal differentiation markers. The LIM domain of P-Lira specifically interacts with the Pit-1 POU domain and is required for synergistic interactions with Pit- 1, but not for basal transcriptional activation events.

Original languageEnglish (US)
Pages (from-to)2720-2724
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume92
Issue number7
DOIs
StatePublished - Mar 28 1995
Externally publishedYes

Keywords

  • POU domain
  • development

ASJC Scopus subject areas

  • General

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