P2 receptors in atherosclerosis and postangioplasty restenosis

Cheikh I. Seye, Qiongman Kong, Ningpu Yu, Fernando A. Gonzalez, Laurie Erb, Gary A. Weisman

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Atherosclerosis is an immunoinflammatory process that involves complex interactions between the vessel wall and blood components and is thought to be initiated by endothelial dysfunction [1-3]. Extracellular nucleotides that are released from a variety of arterial and blood cells [4] can bind to P2 receptors and modulate proliferation and migration of smooth muscle cells (SMC), which is known to be involved in intimal hyperplasia that accompanies atherosclerosis and postangioplasty restenosis [5]. In addition, P2 receptors mediate many other functions, including platelet aggregation, leukocyte adherence, and arterial vasomotoricity. A direct pathological role of P2 receptors is reinforced by recent evidence showing that up-regulation and activation of P2Y2 receptors in rabbit arteries mediates intimal hyperplasia [6]. In addition, up-regulation of functional P2Y receptors also has been demonstrated in the basilar artery of the rat double-hemorrhage model [7] and in coronary arteries of diabetic dyslipidemic pigs [8]. It has been proposed that up-regulation of P2Y receptors may be a potential diagnostic indicator for the early stages of atherosclerosis [9]. Therefore, particular effort must be made to understand the consequences of nucleotide release from cells in the cardiovascular system and the subsequent effects of P2 nucleotide receptor activation in blood vessels, which may reveal novel therapeutic strategies for atherosclerosis and restenosis after angioplasty.

Original languageEnglish (US)
Pages (from-to)471-480
Number of pages10
JournalPurinergic Signalling
Volume2
Issue number3
DOIs
StatePublished - Sep 2006

Keywords

  • Atherosclerosis
  • Inflammation
  • Migration
  • Nucleotide receptors
  • Proliferation
  • Restenosis
  • Smooth muscle cell

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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    Seye, C. I., Kong, Q., Yu, N., Gonzalez, F. A., Erb, L., & Weisman, G. A. (2006). P2 receptors in atherosclerosis and postangioplasty restenosis. Purinergic Signalling, 2(3), 471-480. https://doi.org/10.1007/s11302-006-9015-1