P2 receptors in health and disease

Gary A. Weisman, Ningpu Yu, Zhongji Liao, Fernando Gonzaléz, Laurie Erb, Cheikh Seye

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In the past ten years since the discovery and cloning of members of the P2 receptor family, rapid progress has been made in the field regarding the function and pharmacology of different P2 receptor subtypes. This research resulted in identifying these receptors as important players in the pathology of atherosclerosis, cystic fibrosis, neurodegenerative and autoimmune diseases, among other disorders. The signalling mechanisms whereby P2 receptors mediate pathogenesis are not clear in most cases. Future studies in this field will focus on the integration of signalling pathways coupled to P2 receptors and the generation of specific agonists/antagonists for each receptor subtype to provide strategies for the treatment of a variety of diseases.

Original languageEnglish (US)
Pages (from-to)171-195
Number of pages25
JournalBiotechnology and Genetic Engineering Reviews
Volume22
StatePublished - 2005
Externally publishedYes

Fingerprint

Cystic Fibrosis
Neurodegenerative Diseases
Autoimmune Diseases
Organism Cloning
Atherosclerosis
Health
Pharmacology
Pathology
Cloning
Research
Therapeutics

ASJC Scopus subject areas

  • Biotechnology
  • Genetics
  • Bioengineering

Cite this

Weisman, G. A., Yu, N., Liao, Z., Gonzaléz, F., Erb, L., & Seye, C. (2005). P2 receptors in health and disease. Biotechnology and Genetic Engineering Reviews, 22, 171-195.

P2 receptors in health and disease. / Weisman, Gary A.; Yu, Ningpu; Liao, Zhongji; Gonzaléz, Fernando; Erb, Laurie; Seye, Cheikh.

In: Biotechnology and Genetic Engineering Reviews, Vol. 22, 2005, p. 171-195.

Research output: Contribution to journalArticle

Weisman, GA, Yu, N, Liao, Z, Gonzaléz, F, Erb, L & Seye, C 2005, 'P2 receptors in health and disease', Biotechnology and Genetic Engineering Reviews, vol. 22, pp. 171-195.
Weisman GA, Yu N, Liao Z, Gonzaléz F, Erb L, Seye C. P2 receptors in health and disease. Biotechnology and Genetic Engineering Reviews. 2005;22:171-195.
Weisman, Gary A. ; Yu, Ningpu ; Liao, Zhongji ; Gonzaléz, Fernando ; Erb, Laurie ; Seye, Cheikh. / P2 receptors in health and disease. In: Biotechnology and Genetic Engineering Reviews. 2005 ; Vol. 22. pp. 171-195.
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