P300 from an auditory oddball task: inter-laboratory consistency

Joel E. Alexander, John Polich, Floyd E. Bloom, Lance O. Bauer, Samuel Kuperman, John Rohrbaugh, Sandra Morzorati, Sean J. O'Connor, Bernice Porjesz, Henri Begleiter

Research output: Contribution to journalArticle

28 Scopus citations


Event-related potentials (ERPs) were recorded from normal subjects for the purpose of evaluating measurement consistency among six laboratories located in different cities within the United States. At each laboratory location 15 male subjects were tested using a simple auditory stimulus discrimination task and identical electrophysiological equipment and recording methods. Assessment of the N1, P2, N2, and P3(00) potentials from both the target and standard stimuli resulted in no reliable differences among laboratories for component amplitudes, latencies, and scalp distributions. Quantitative evaluation of overall waveform and specific component morphology yielded good to excellent agreement across laboratories. The findings suggest that large-scale inter-laboratory human electrophysiological studies are feasible and may prove of value when using ERPs to evaluate cognitive function in humans.

Original languageEnglish (US)
Pages (from-to)35-46
Number of pages12
JournalInternational Journal of Psychophysiology
Issue number1
StatePublished - Jun 1994


  • Consistency
  • Event-related potentials
  • Multi-laboratory recording
  • P300

ASJC Scopus subject areas

  • Behavioral Neuroscience

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    Alexander, J. E., Polich, J., Bloom, F. E., Bauer, L. O., Kuperman, S., Rohrbaugh, J., Morzorati, S., O'Connor, S. J., Porjesz, B., & Begleiter, H. (1994). P300 from an auditory oddball task: inter-laboratory consistency. International Journal of Psychophysiology, 17(1), 35-46. https://doi.org/10.1016/0167-8760(94)90053-1