p38 MAP kinase--a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability.

Katja Issbrücker, Hugo H. Marti, Stefan Hippenstiel, Georg Springmann, Robert Voswinckel, Andreas Gaumann, Georg Breier, Hannes C A Drexler, Norbert Suttorp, Matthias Clauss

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Vascular endothelial growth factor (VEGF) is not only essential for vasculogenesis and angiogenesis but also is a potent inducer of vascular permeability. Although a dissection of the molecular pathways between angiogenesis- and vascular permeability-inducing properties would be desirable for the development of angiogenic and anti-angiogenic therapies, such mechanisms have not been identified yet. Here we provide evidence for a role of the p38 MAPK as the signaling molecule that separates these two processes. Inhibition of p38 MAPK activity enhances VEGF-induced angiogenesis in vitro and in vivo, a finding that was accompanied by prolonged Erk1/2 MAPK activation, increased endothelial survival, and plasminogen activation. Conversely, the same inhibitors abrogate VEGF-induced vascular permeability in vitro and in vivo. These dualistic properties of p38 MAPK are relevant not only for therapeutic angiogenesis but also for reducing edema formation and enhancing tissue repair in ischemic diseases.

Original languageEnglish
Pages (from-to)262-264
Number of pages3
JournalFASEB Journal
Volume17
Issue number2
StatePublished - 2003
Externally publishedYes

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Capillary Permeability
p38 Mitogen-Activated Protein Kinases
Vascular Endothelial Growth Factor A
Blood Vessels
Switches
Chemical activation
Dissection
Plasminogen
Edema
Repair
Tissue
Molecules
Therapeutics
In Vitro Techniques

Cite this

Issbrücker, K., Marti, H. H., Hippenstiel, S., Springmann, G., Voswinckel, R., Gaumann, A., ... Clauss, M. (2003). p38 MAP kinase--a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability. FASEB Journal, 17(2), 262-264.

p38 MAP kinase--a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability. / Issbrücker, Katja; Marti, Hugo H.; Hippenstiel, Stefan; Springmann, Georg; Voswinckel, Robert; Gaumann, Andreas; Breier, Georg; Drexler, Hannes C A; Suttorp, Norbert; Clauss, Matthias.

In: FASEB Journal, Vol. 17, No. 2, 2003, p. 262-264.

Research output: Contribution to journalArticle

Issbrücker, K, Marti, HH, Hippenstiel, S, Springmann, G, Voswinckel, R, Gaumann, A, Breier, G, Drexler, HCA, Suttorp, N & Clauss, M 2003, 'p38 MAP kinase--a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability.', FASEB Journal, vol. 17, no. 2, pp. 262-264.
Issbrücker K, Marti HH, Hippenstiel S, Springmann G, Voswinckel R, Gaumann A et al. p38 MAP kinase--a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability. FASEB Journal. 2003;17(2):262-264.
Issbrücker, Katja ; Marti, Hugo H. ; Hippenstiel, Stefan ; Springmann, Georg ; Voswinckel, Robert ; Gaumann, Andreas ; Breier, Georg ; Drexler, Hannes C A ; Suttorp, Norbert ; Clauss, Matthias. / p38 MAP kinase--a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability. In: FASEB Journal. 2003 ; Vol. 17, No. 2. pp. 262-264.
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