P38 MAPK in pancreatic cancer: Finding a protective needle in the haystack

Murray Korc

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Activated p38 MAPK alpha (pp38α) is a good prognostic marker in pancreatic ductal adenocarcinoma that could be used to personalize therapy. pp38α suppresses JNK-mediated proliferation, both in vitro and in vivo. These findings support the testing of combination therapies that include JNK targeting and/or suppressing negative regulators of pp38α.

Original languageEnglish (US)
Pages (from-to)5866-5868
Number of pages3
JournalClinical Cancer Research
Volume20
Issue number23
DOIs
StatePublished - Dec 1 2014

Fingerprint

p38 Mitogen-Activated Protein Kinases
Pancreatic Neoplasms
Needles
Adenocarcinoma
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

P38 MAPK in pancreatic cancer : Finding a protective needle in the haystack. / Korc, Murray.

In: Clinical Cancer Research, Vol. 20, No. 23, 01.12.2014, p. 5866-5868.

Research output: Contribution to journalArticle

@article{0328f585142a40e59023df624e16dbbf,
title = "P38 MAPK in pancreatic cancer: Finding a protective needle in the haystack",
abstract = "Activated p38 MAPK alpha (pp38α) is a good prognostic marker in pancreatic ductal adenocarcinoma that could be used to personalize therapy. pp38α suppresses JNK-mediated proliferation, both in vitro and in vivo. These findings support the testing of combination therapies that include JNK targeting and/or suppressing negative regulators of pp38α.",
author = "Murray Korc",
year = "2014",
month = "12",
day = "1",
doi = "10.1158/1078-0432.CCR-14-1543",
language = "English (US)",
volume = "20",
pages = "5866--5868",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "23",

}

TY - JOUR

T1 - P38 MAPK in pancreatic cancer

T2 - Finding a protective needle in the haystack

AU - Korc, Murray

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Activated p38 MAPK alpha (pp38α) is a good prognostic marker in pancreatic ductal adenocarcinoma that could be used to personalize therapy. pp38α suppresses JNK-mediated proliferation, both in vitro and in vivo. These findings support the testing of combination therapies that include JNK targeting and/or suppressing negative regulators of pp38α.

AB - Activated p38 MAPK alpha (pp38α) is a good prognostic marker in pancreatic ductal adenocarcinoma that could be used to personalize therapy. pp38α suppresses JNK-mediated proliferation, both in vitro and in vivo. These findings support the testing of combination therapies that include JNK targeting and/or suppressing negative regulators of pp38α.

UR - http://www.scopus.com/inward/record.url?scp=84918548940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84918548940&partnerID=8YFLogxK

U2 - 10.1158/1078-0432.CCR-14-1543

DO - 10.1158/1078-0432.CCR-14-1543

M3 - Article

C2 - 25135483

AN - SCOPUS:84918548940

VL - 20

SP - 5866

EP - 5868

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 23

ER -