P38 MAPK in pancreatic cancer: Finding a protective needle in the haystack

Murray Korc

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Activated p38 MAPK alpha (pp38α) is a good prognostic marker in pancreatic ductal adenocarcinoma that could be used to personalize therapy. pp38α suppresses JNK-mediated proliferation, both in vitro and in vivo. These findings support the testing of combination therapies that include JNK targeting and/or suppressing negative regulators of pp38α.

Original languageEnglish (US)
Pages (from-to)5866-5868
Number of pages3
JournalClinical Cancer Research
Volume20
Issue number23
DOIs
StatePublished - Dec 1 2014

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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