P450 metabolism in fibromyalgia

Daniel J. Clauw, Jan Hewett, Carolyn A. Blank, Paul Katz, David A. Flockhart

Research output: Contribution to journalArticle

Abstract

Objectives: To determine if the perceived high incidence of hypersensitivity to various substance in firomyalgia, including medications, due to abnormal P450 xenobiotic metabolism. Methods: The metabolism via two genetically polymorphic P450 pathways was determined for 33 fibromyalgia patients, and matched controls. Results: There was no statistical difference between the genotypic frequency of the CYP2D6 gene or phenotypic expression of CYP2C19 between patients and contorls. Conclusion: Xenobiotic metabolism by the two pathways studied is normal in fibromyalgia. Although other P450 pathways could conceivably be abnormal in fibromyalgia, we speculate that such hypersensitivity to multiple substances in these conditions is unlikely to be due to abnormal metabolism, and postulate instead that these symptoms are mediated by neural mechanisms.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalJournal of Musculoskeletal Pain
Volume3
Issue number4
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Fibromyalgia
Xenobiotics
Hypersensitivity
Cytochrome P-450 CYP2D6
Gene Frequency
Incidence

Keywords

  • Fibromyalgia
  • Metabolism
  • P450 enzymes
  • Xenobiotic

ASJC Scopus subject areas

  • Rheumatology
  • Health Professions(all)

Cite this

Clauw, D. J., Hewett, J., Blank, C. A., Katz, P., & Flockhart, D. A. (1995). P450 metabolism in fibromyalgia. Journal of Musculoskeletal Pain, 3(4), 25-32. https://doi.org/10.1300/J094v03n04_04

P450 metabolism in fibromyalgia. / Clauw, Daniel J.; Hewett, Jan; Blank, Carolyn A.; Katz, Paul; Flockhart, David A.

In: Journal of Musculoskeletal Pain, Vol. 3, No. 4, 1995, p. 25-32.

Research output: Contribution to journalArticle

Clauw, DJ, Hewett, J, Blank, CA, Katz, P & Flockhart, DA 1995, 'P450 metabolism in fibromyalgia', Journal of Musculoskeletal Pain, vol. 3, no. 4, pp. 25-32. https://doi.org/10.1300/J094v03n04_04
Clauw DJ, Hewett J, Blank CA, Katz P, Flockhart DA. P450 metabolism in fibromyalgia. Journal of Musculoskeletal Pain. 1995;3(4):25-32. https://doi.org/10.1300/J094v03n04_04
Clauw, Daniel J. ; Hewett, Jan ; Blank, Carolyn A. ; Katz, Paul ; Flockhart, David A. / P450 metabolism in fibromyalgia. In: Journal of Musculoskeletal Pain. 1995 ; Vol. 3, No. 4. pp. 25-32.
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