p53 Mutations are common in pancreatic cancer and are absent in chronic pancreatitis

Graham Casey, Yoichiro Yamanaka, Helmut Friess, Michael S. Kobrin, Martha E. Lopez, Markus Buchler, Hans G. Beger, Murray Korc

Research output: Contribution to journalArticle

178 Scopus citations

Abstract

Pancreatic expression of the p53 tumor suppressor gene was studied in pancreatic adenocarcinomas and chronic pancreatitis. By immunohistochemistry, 16 of 34 (47%) cancers and none of the 24 chronic pancreatitis samples revealed nuclear staining. Sequence analysis indicated that 8 of 24 (33%) cancers were mutated for the p53 gene. Point substitutions occurred at codons 35, 105, 133, 213, 213, 258, and 299. A three base-pair inframe insertion was identified between codons 261 and 262. None of 8 chronic pancreatitis samples exhibited p53 gene mutations. These data support a role for p53 gene alterations in human pancreatic cancer, and suggest that loss of its regulatory functions may constitute one of the differences between pancreatic cancer and chronic pancreatitis.

Original languageEnglish (US)
Pages (from-to)151-160
Number of pages10
JournalCancer Letters
Volume69
Issue number3
DOIs
StatePublished - May 14 1993

Keywords

  • immunohistochemistry
  • p53
  • pancreatic cancer
  • sequencing

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Casey, G., Yamanaka, Y., Friess, H., Kobrin, M. S., Lopez, M. E., Buchler, M., Beger, H. G., & Korc, M. (1993). p53 Mutations are common in pancreatic cancer and are absent in chronic pancreatitis. Cancer Letters, 69(3), 151-160. https://doi.org/10.1016/0304-3835(93)90168-9