P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression

Sachiyo Okayama, Levy Kopelovich, Gabriel Balmus, Robert S. Weiss, Brittney Shea Herbert, Andrew J. Dannenberg, Kotha Subbaramaiah

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Background: The mechanism by which p53, a tumor suppressor gene, regulates Wnt signaling is incompletely understood. Results: p53 modulates Hsp90 ATPase activity via effects on Aha1 leading to changes in the expression of Wnt target genes. Conclusion: p53 regulates Hsp90 ATPase activity and thereby Wnt signaling. Significance: We describe a new mechanism by which p53 affects Wnt signaling.

Original languageEnglish (US)
Pages (from-to)6513-6525
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number10
DOIs
StatePublished - Mar 7 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression'. Together they form a unique fingerprint.

  • Cite this

    Okayama, S., Kopelovich, L., Balmus, G., Weiss, R. S., Herbert, B. S., Dannenberg, A. J., & Subbaramaiah, K. (2014). P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression. Journal of Biological Chemistry, 289(10), 6513-6525. https://doi.org/10.1074/jbc.M113.532523