P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression

Sachiyo Okayama, Levy Kopelovich, Gabriel Balmus, Robert S. Weiss, Brittney-Shea Herbert, Andrew J. Dannenberg, Kotha Subbaramaiah

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: The mechanism by which p53, a tumor suppressor gene, regulates Wnt signaling is incompletely understood. Results: p53 modulates Hsp90 ATPase activity via effects on Aha1 leading to changes in the expression of Wnt target genes. Conclusion: p53 regulates Hsp90 ATPase activity and thereby Wnt signaling. Significance: We describe a new mechanism by which p53 affects Wnt signaling.

Original languageEnglish
Pages (from-to)6513-6525
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number10
DOIs
StatePublished - Mar 7 2014

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Adenosine Triphosphatases
Genes
Tumor Suppressor Genes
Proteins
Tumors

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Okayama, S., Kopelovich, L., Balmus, G., Weiss, R. S., Herbert, B-S., Dannenberg, A. J., & Subbaramaiah, K. (2014). P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression. Journal of Biological Chemistry, 289(10), 6513-6525. https://doi.org/10.1074/jbc.M113.532523

P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression. / Okayama, Sachiyo; Kopelovich, Levy; Balmus, Gabriel; Weiss, Robert S.; Herbert, Brittney-Shea; Dannenberg, Andrew J.; Subbaramaiah, Kotha.

In: Journal of Biological Chemistry, Vol. 289, No. 10, 07.03.2014, p. 6513-6525.

Research output: Contribution to journalArticle

Okayama, S, Kopelovich, L, Balmus, G, Weiss, RS, Herbert, B-S, Dannenberg, AJ & Subbaramaiah, K 2014, 'P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression', Journal of Biological Chemistry, vol. 289, no. 10, pp. 6513-6525. https://doi.org/10.1074/jbc.M113.532523
Okayama, Sachiyo ; Kopelovich, Levy ; Balmus, Gabriel ; Weiss, Robert S. ; Herbert, Brittney-Shea ; Dannenberg, Andrew J. ; Subbaramaiah, Kotha. / P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 10. pp. 6513-6525.
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