Low-affinity p75 neurotrophin receptor (p75(NTR)) immunoreactivity in the aged human hypothalamus was examined in autopsied material. Numerous p75(NTR)-immunoreactive cells were found in the paraventricular and supraoptic hypothalamic nuclei. The suprachiasmatic nucleus was devoid of p75(NTR)-immunostaining. Many p75(NTR)-immunoreactive fibers extended laterally and ventrally from the paraventricular and supraoptic nuclei into the pituitary stalk and median eminence. Our results suggest that neurotrophins may be present within the human hypothalamo-hypophyseal system.
- Nerve growth factor
- Paraventricular hypothalamic nucleus
- Suprachiasmatic nucleus
- Supraoptic nucleus
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