Paced respiration for vasomotor and other menopausal symptoms

A randomized, controlled trial

Janet Carpenter, Debra S. Burns, Jingwei Wu, Julie Otte, Bryan Schneider, Kristin Ryker, Eileen Tallman, Menggang Yu

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

BACKGROUND: Paced respiration has been internationally recommended for vasomotor symptom management, despite limited empirical evidence. OBJECTIVE: To evaluate efficacy of a paced respiration intervention against breathing control and usual care control for vasomotor and other menopausal symptoms. DESIGN: A 16-week, 3-group, partially blinded, controlled trial with 2:2:1 randomization and stratification by group (breast cancer, no cancer), in a Midwestern city and surrounding area. PARTICIPANTS: Two hundred and eighteen randomized women (96 breast cancer survivors, 122 menopausal women without cancer), recruited through community mailings and registries (29 % minority). INTERVENTIONS: Training, home practice support, and instructions to use the breathing at the time of each hot flash were delivered via compact disc with printed booklet (paced respiration intervention) or digital videodisc with printed booklet (fast shallow breathing control). Usual care control received a letter regarding group assignment. MAIN MEASURES: Hot flash frequency, severity, and bother (primary); hot flash interference in daily life, perceived control over hot flashes, and mood and sleep disturbances (secondary). Intervention performance, adherence, and adverse events were assessed. KEY RESULTS: There were no significant group differences for primary outcomes at 8-weeks or 16-weeks post-randomization. Most intervention participants did not achieve 50 % reduction in vasomotor symptoms, despite demonstrated ability to correctly do paced respiration and daily practice. Statistically significant differences in secondary outcomes at 8 and 16 weeks were small, not likely to be clinically relevant, and as likely to favor intervention as breathing control. CONCLUSIONS: Paced respiration is unlikely to provide clinical benefit for vasomotor or other menopausal symptoms in breast cancer survivors or menopausal women without cancer.

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalJournal of General Internal Medicine
Volume28
Issue number2
DOIs
StatePublished - Feb 2013

Fingerprint

Respiration
Randomized Controlled Trials
Hot Flashes
Pamphlets
Breast Neoplasms
Random Allocation
Survivors
Neoplasms
Aptitude
Registries
Sleep

Keywords

  • menopausal symptoms
  • menopause
  • paced respiration
  • vasomotor symptoms

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Paced respiration for vasomotor and other menopausal symptoms : A randomized, controlled trial. / Carpenter, Janet; Burns, Debra S.; Wu, Jingwei; Otte, Julie; Schneider, Bryan; Ryker, Kristin; Tallman, Eileen; Yu, Menggang.

In: Journal of General Internal Medicine, Vol. 28, No. 2, 02.2013, p. 193-200.

Research output: Contribution to journalArticle

Carpenter, Janet ; Burns, Debra S. ; Wu, Jingwei ; Otte, Julie ; Schneider, Bryan ; Ryker, Kristin ; Tallman, Eileen ; Yu, Menggang. / Paced respiration for vasomotor and other menopausal symptoms : A randomized, controlled trial. In: Journal of General Internal Medicine. 2013 ; Vol. 28, No. 2. pp. 193-200.
@article{f94c8d42fee64de2b63566be8f045687,
title = "Paced respiration for vasomotor and other menopausal symptoms: A randomized, controlled trial",
abstract = "BACKGROUND: Paced respiration has been internationally recommended for vasomotor symptom management, despite limited empirical evidence. OBJECTIVE: To evaluate efficacy of a paced respiration intervention against breathing control and usual care control for vasomotor and other menopausal symptoms. DESIGN: A 16-week, 3-group, partially blinded, controlled trial with 2:2:1 randomization and stratification by group (breast cancer, no cancer), in a Midwestern city and surrounding area. PARTICIPANTS: Two hundred and eighteen randomized women (96 breast cancer survivors, 122 menopausal women without cancer), recruited through community mailings and registries (29 {\%} minority). INTERVENTIONS: Training, home practice support, and instructions to use the breathing at the time of each hot flash were delivered via compact disc with printed booklet (paced respiration intervention) or digital videodisc with printed booklet (fast shallow breathing control). Usual care control received a letter regarding group assignment. MAIN MEASURES: Hot flash frequency, severity, and bother (primary); hot flash interference in daily life, perceived control over hot flashes, and mood and sleep disturbances (secondary). Intervention performance, adherence, and adverse events were assessed. KEY RESULTS: There were no significant group differences for primary outcomes at 8-weeks or 16-weeks post-randomization. Most intervention participants did not achieve 50 {\%} reduction in vasomotor symptoms, despite demonstrated ability to correctly do paced respiration and daily practice. Statistically significant differences in secondary outcomes at 8 and 16 weeks were small, not likely to be clinically relevant, and as likely to favor intervention as breathing control. CONCLUSIONS: Paced respiration is unlikely to provide clinical benefit for vasomotor or other menopausal symptoms in breast cancer survivors or menopausal women without cancer.",
keywords = "menopausal symptoms, menopause, paced respiration, vasomotor symptoms",
author = "Janet Carpenter and Burns, {Debra S.} and Jingwei Wu and Julie Otte and Bryan Schneider and Kristin Ryker and Eileen Tallman and Menggang Yu",
year = "2013",
month = "2",
doi = "10.1007/s11606-012-2202-6",
language = "English",
volume = "28",
pages = "193--200",
journal = "Journal of General Internal Medicine",
issn = "0884-8734",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Paced respiration for vasomotor and other menopausal symptoms

T2 - A randomized, controlled trial

AU - Carpenter, Janet

AU - Burns, Debra S.

AU - Wu, Jingwei

AU - Otte, Julie

AU - Schneider, Bryan

AU - Ryker, Kristin

AU - Tallman, Eileen

AU - Yu, Menggang

PY - 2013/2

Y1 - 2013/2

N2 - BACKGROUND: Paced respiration has been internationally recommended for vasomotor symptom management, despite limited empirical evidence. OBJECTIVE: To evaluate efficacy of a paced respiration intervention against breathing control and usual care control for vasomotor and other menopausal symptoms. DESIGN: A 16-week, 3-group, partially blinded, controlled trial with 2:2:1 randomization and stratification by group (breast cancer, no cancer), in a Midwestern city and surrounding area. PARTICIPANTS: Two hundred and eighteen randomized women (96 breast cancer survivors, 122 menopausal women without cancer), recruited through community mailings and registries (29 % minority). INTERVENTIONS: Training, home practice support, and instructions to use the breathing at the time of each hot flash were delivered via compact disc with printed booklet (paced respiration intervention) or digital videodisc with printed booklet (fast shallow breathing control). Usual care control received a letter regarding group assignment. MAIN MEASURES: Hot flash frequency, severity, and bother (primary); hot flash interference in daily life, perceived control over hot flashes, and mood and sleep disturbances (secondary). Intervention performance, adherence, and adverse events were assessed. KEY RESULTS: There were no significant group differences for primary outcomes at 8-weeks or 16-weeks post-randomization. Most intervention participants did not achieve 50 % reduction in vasomotor symptoms, despite demonstrated ability to correctly do paced respiration and daily practice. Statistically significant differences in secondary outcomes at 8 and 16 weeks were small, not likely to be clinically relevant, and as likely to favor intervention as breathing control. CONCLUSIONS: Paced respiration is unlikely to provide clinical benefit for vasomotor or other menopausal symptoms in breast cancer survivors or menopausal women without cancer.

AB - BACKGROUND: Paced respiration has been internationally recommended for vasomotor symptom management, despite limited empirical evidence. OBJECTIVE: To evaluate efficacy of a paced respiration intervention against breathing control and usual care control for vasomotor and other menopausal symptoms. DESIGN: A 16-week, 3-group, partially blinded, controlled trial with 2:2:1 randomization and stratification by group (breast cancer, no cancer), in a Midwestern city and surrounding area. PARTICIPANTS: Two hundred and eighteen randomized women (96 breast cancer survivors, 122 menopausal women without cancer), recruited through community mailings and registries (29 % minority). INTERVENTIONS: Training, home practice support, and instructions to use the breathing at the time of each hot flash were delivered via compact disc with printed booklet (paced respiration intervention) or digital videodisc with printed booklet (fast shallow breathing control). Usual care control received a letter regarding group assignment. MAIN MEASURES: Hot flash frequency, severity, and bother (primary); hot flash interference in daily life, perceived control over hot flashes, and mood and sleep disturbances (secondary). Intervention performance, adherence, and adverse events were assessed. KEY RESULTS: There were no significant group differences for primary outcomes at 8-weeks or 16-weeks post-randomization. Most intervention participants did not achieve 50 % reduction in vasomotor symptoms, despite demonstrated ability to correctly do paced respiration and daily practice. Statistically significant differences in secondary outcomes at 8 and 16 weeks were small, not likely to be clinically relevant, and as likely to favor intervention as breathing control. CONCLUSIONS: Paced respiration is unlikely to provide clinical benefit for vasomotor or other menopausal symptoms in breast cancer survivors or menopausal women without cancer.

KW - menopausal symptoms

KW - menopause

KW - paced respiration

KW - vasomotor symptoms

UR - http://www.scopus.com/inward/record.url?scp=84871566481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871566481&partnerID=8YFLogxK

U2 - 10.1007/s11606-012-2202-6

DO - 10.1007/s11606-012-2202-6

M3 - Article

VL - 28

SP - 193

EP - 200

JO - Journal of General Internal Medicine

JF - Journal of General Internal Medicine

SN - 0884-8734

IS - 2

ER -