PAFc, a key player in MLL-rearranged leukemogenesis.

Jiaying Tan, Andrew G. Muntean, Jay L. Hess

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Recent studies identified an interaction between the Polymerase Associated Factor complex (PAFc) and Mixed Lineage Leukemia (MLL), including MLL-rearranged oncoproteins. This interaction is critical for MLL transcriptional activity and MLL-rearranged leukemogenesis. Here, we discuss the potential molecular role of the PAFc in transcriptional dysregulation of MLL target genes and the interplay between PAFc and MLL-rearranged oncoproteins in leukemogenesis.

Original languageEnglish (US)
Pages (from-to)461-465
Number of pages5
JournalOncotarget
Volume1
Issue number6
DOIs
StatePublished - Oct 2010

ASJC Scopus subject areas

  • Oncology

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