PAFc, a key player in MLL-rearranged leukemogenesis.

Jiaying Tan, Andrew G. Muntean, Jay Hess

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Recent studies identified an interaction between the Polymerase Associated Factor complex (PAFc) and Mixed Lineage Leukemia (MLL), including MLL-rearranged oncoproteins. This interaction is critical for MLL transcriptional activity and MLL-rearranged leukemogenesis. Here, we discuss the potential molecular role of the PAFc in transcriptional dysregulation of MLL target genes and the interplay between PAFc and MLL-rearranged oncoproteins in leukemogenesis.

Original languageEnglish (US)
Pages (from-to)461-465
Number of pages5
JournalOncotarget
Volume1
Issue number6
StatePublished - Oct 2010
Externally publishedYes

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Leukemia
Oncogene Proteins
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tan, J., Muntean, A. G., & Hess, J. (2010). PAFc, a key player in MLL-rearranged leukemogenesis. Oncotarget, 1(6), 461-465.

PAFc, a key player in MLL-rearranged leukemogenesis. / Tan, Jiaying; Muntean, Andrew G.; Hess, Jay.

In: Oncotarget, Vol. 1, No. 6, 10.2010, p. 461-465.

Research output: Contribution to journalArticle

Tan, J, Muntean, AG & Hess, J 2010, 'PAFc, a key player in MLL-rearranged leukemogenesis.', Oncotarget, vol. 1, no. 6, pp. 461-465.
Tan, Jiaying ; Muntean, Andrew G. ; Hess, Jay. / PAFc, a key player in MLL-rearranged leukemogenesis. In: Oncotarget. 2010 ; Vol. 1, No. 6. pp. 461-465.
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