Paget disease of bone

Julia F. Charles, Ethel S. Siris, G. David Roodman

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


This chapter describes definition, etiology, pathology, diagnosis, treatment and management of Paget disease of bone. This is the second most common bone disease after osteoporosis. Both genetic and environmental factors have been implicated in the pathogenesis of Paget disease. Paget disease occurs commonly in families and can be transmitted vertically in an autosomal dominant pattern. Pagetic bone contains more numerous osteoclasts than normal, and these osteoclasts contain substantially more nuclei than normal osteoclasts. When Paget disease is suspected, the diagnostic evaluation should include a careful medical history, including family history of the condition and symptom history, and a focused physical examination. Laboratory tests include measurement of serum total alkaline phosphatase (SAP), and serum calcium and 25-hydroxyvitamin D if bisphosphonate treatment is considered. Current guidelines suggest treatment of most patients with active disease at risk for complications with high potency bisphosphonates, either intravenous zolendronic acid, or oral alendronate or risedronate.

Original languageEnglish (US)
Title of host publicationPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
Number of pages8
ISBN (Electronic)9781119266594
ISBN (Print)9781119266563
StatePublished - Jan 1 2018


  • 25-hydroxyvitamin D measurement
  • Intravenous zolendronic acid
  • Metabolic bone diseases
  • Oral alendronate
  • Paget disease
  • SAP measurement
  • Serum calcium measurement

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Paget disease of bone'. Together they form a unique fingerprint.

  • Cite this

    Charles, J. F., Siris, E. S., & Roodman, G. D. (2018). Paget disease of bone. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (pp. 713-720). wiley.