Abstract
This chapter discusses the etiology, pathology, clinical features, diagnosis, and treatment of Paget's disease. Although Paget's disease is the second most common bone disease after osteoporosis, the factors involved in its pathogenesis are just beginning to be clarified. Both genetic and environmental factors have been implicated in the pathophysiology of Paget's disease. The initiating lesion in Paget's disease is an increase in bone resorption due to an abnormality in the osteoclasts found at affected sites. Measurements of biochemical markers of bone turnover are useful clinically in the assessment of the extent and severity of disease in the untreated state and for monitoring the response to treatment. Specific antipagetic therapy consists of those agents capable of suppressing the activity of pagetic osteoclasts. Other symptomatic treatments for Paget's disease, including analgesics, anti-inflammatory drugs, use of orthotics or canes, and selected orthopedic and neurosurgical interventions, have important roles in management in many patients.
| Original language | English (US) |
|---|---|
| Title of host publication | Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition |
| Publisher | Wiley Blackwell |
| Pages | 659-668 |
| Number of pages | 10 |
| ISBN (Electronic) | 9781118453926 |
| ISBN (Print) | 9781118453889 |
| DOIs | |
| State | Published - Jul 19 2013 |
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Keywords
- Antipagetic therapy
- Bone remodeling
- Osteoporosis
- Paget's disease
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Paget's Disease of Bone. / Siris, Ethel S.; Roodman, G. David.
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, 2013. p. 659-668.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Paget's Disease of Bone
AU - Siris, Ethel S.
AU - Roodman, G. David
PY - 2013/7/19
Y1 - 2013/7/19
N2 - This chapter discusses the etiology, pathology, clinical features, diagnosis, and treatment of Paget's disease. Although Paget's disease is the second most common bone disease after osteoporosis, the factors involved in its pathogenesis are just beginning to be clarified. Both genetic and environmental factors have been implicated in the pathophysiology of Paget's disease. The initiating lesion in Paget's disease is an increase in bone resorption due to an abnormality in the osteoclasts found at affected sites. Measurements of biochemical markers of bone turnover are useful clinically in the assessment of the extent and severity of disease in the untreated state and for monitoring the response to treatment. Specific antipagetic therapy consists of those agents capable of suppressing the activity of pagetic osteoclasts. Other symptomatic treatments for Paget's disease, including analgesics, anti-inflammatory drugs, use of orthotics or canes, and selected orthopedic and neurosurgical interventions, have important roles in management in many patients.
AB - This chapter discusses the etiology, pathology, clinical features, diagnosis, and treatment of Paget's disease. Although Paget's disease is the second most common bone disease after osteoporosis, the factors involved in its pathogenesis are just beginning to be clarified. Both genetic and environmental factors have been implicated in the pathophysiology of Paget's disease. The initiating lesion in Paget's disease is an increase in bone resorption due to an abnormality in the osteoclasts found at affected sites. Measurements of biochemical markers of bone turnover are useful clinically in the assessment of the extent and severity of disease in the untreated state and for monitoring the response to treatment. Specific antipagetic therapy consists of those agents capable of suppressing the activity of pagetic osteoclasts. Other symptomatic treatments for Paget's disease, including analgesics, anti-inflammatory drugs, use of orthotics or canes, and selected orthopedic and neurosurgical interventions, have important roles in management in many patients.
KW - Antipagetic therapy
KW - Bone remodeling
KW - Osteoporosis
KW - Paget's disease
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UR - http://www.scopus.com/inward/citedby.url?scp=84945570230&partnerID=8YFLogxK
U2 - 10.1002/9781118453926.ch80
DO - 10.1002/9781118453926.ch80
M3 - Chapter
AN - SCOPUS:84945570230
SN - 9781118453889
SP - 659
EP - 668
BT - Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition
PB - Wiley Blackwell
ER -