Paget’s disease of bone

Frederick R. Singer, G. David Roodman

Research output: Chapter in Book/Report/Conference proceedingChapter


Paget’s disease is a common disorder of the skeleton that is local in nature and extremely variable in its clinical manifestation. The majority of patients are without symptoms. When symptoms are present, skeletal deformity and pain are most common. Deformities are usually most apparent in the skull, face, and lower extremities. Pain is of several origins. Localized bone pain is surprisingly uncommon, but joint pain (hips and knees) is seen not infrequently, owing to degenerative arthritis. Pain of neural or spinal origin is unusual but the most severe. Both genetic and environmental etiologies have been implicated in the pathogenesis of Paget’s disease and will be discussed in this chapter.

Original languageEnglish (US)
Title of host publicationPrinciples of Bone Biology
Number of pages13
ISBN (Electronic)9780128148419
StatePublished - Jan 1 2019


  • Bone disorders
  • Osteoclasts
  • Paget’s disease
  • Paramyxovirus
  • Sequestosome 1
  • Skeletal disorders
  • Valosin-containing protein

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Singer, F. R., & Roodman, G. D. (2019). Paget’s disease of bone. In Principles of Bone Biology (pp. 1601-1613). Elsevier.