Paget's Disease of Bone: A Disease of the Osteoclast

Sakamuri V. Reddy, Noriyoshi Kurihara, Cheikh Menaa, G. David Roodman

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Paget's disease is a chronic focal disease of the skeleton that affects up to 2-3% of the population over the age of 60 years. There is a genetic predisposition for Paget's disease, with one predisposition locus identified on chromosome 18q-21-22. Osteoclasts and osteoclast precursors from Paget's patients are abnormal and appear hyperresponsive to 1, 25(OH)2D3 and RANK ligand and contain paramyxoviral transcripts (Fig. 1). The basis for the abnormalities detected in Paget's disease and the role that the paramyxoviruses may play in this disease are still unclear.

Original languageEnglish (US)
Pages (from-to)195-201
Number of pages7
JournalReviews in Endocrine and Metabolic Disorders
Volume2
Issue number2
DOIs
StatePublished - Jan 1 2001

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Keywords

  • Bisphosphonates
  • Measles virus
  • Osteoclast
  • Paget's disease

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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