PALA (NSC-224131) in advanced carcinoma of the cervix. A phase II study of the Gynecologic Oncology Group

H. B. Muss, B. Bundy, P. J. DiSaia, F. B. Stehman, J. Beecham

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Abstract

Thirty-six patients with advanced carcinoma of the cervix received PALA at a dosage of 5 gm/m2 every three weeks. Thirty-three patients had received prior irradiation therapy and chemotherapy. No complete or partial responses were seen. The major toxicity was determatologic and occurred in 16/36 (44%) of patients. Three patients experienced dose limiting disorientation or confusion. PALA was not associated with any antitumor activity in patients with advanced carcinoma of the cervix who had received prior chemotherapy. The results of this study indicate that PALA has no substantial activity in patients with advanced squamous carcinoma of the cervix who have previously received chemotherapy.

Original languageEnglish (US)
Pages (from-to)741-744
Number of pages4
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume7
Issue number6
DOIs
StatePublished - Jan 1 1984

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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