Pancreas Cancer-Associated Weight Loss

on behalf of the Precision Promise Consortium

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Unintentional weight loss in patients with pancreatic cancer is highly prevalent and contributes to low therapeutic tolerance, reduced quality of life, and overall mortality. Weight loss in pancreatic cancer can be due to anorexia, malabsorption, and/or cachexia. Proper supportive care can stabilize or reverse weight loss in patients and improve outcomes. We review the literature on supportive care relevant to pancreatic cancer patients, and offer evidence-based recommendations that include expert nutritional assessment, counseling, supportive measures to ensure adequate caloric intake, pancreatic enzyme supplementation, nutritional supplement replacement, orexigenic agents, and exercise. Pancreatic Cancer Action Network-supported initiatives will spearhead the dissemination and adoption of these best supportive care practices. Implications for Practice: Weight loss in pancreatic cancer patients is endemic, as 85% of pancreatic cancer patients meet the classic definition of cancer cachexia. Despite its significant prevalence and associated morbidity, there is no established approach to this disease entity. It is believed that this is due to an important knowledge gap in understanding the underlying biology and lack of optimal treatment approaches. This article reviews the literature regarding pancreas cancer-associated weight loss and establishes a new framework from which to view this complex clinical problem. An improved approach and understanding will help educate clinicians, improve clinical care, and provide more clarity for future clinical investigation.

Original languageEnglish (US)
JournalOncologist
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Pancreatic Neoplasms
Weight Loss
Cachexia
Nutrition Assessment
Anorexia
Energy Intake
Counseling
Quality of Life
Exercise
Morbidity
Mortality
Enzymes
Therapeutics
Neoplasms

Keywords

  • Anorexia
  • Cachexia
  • Malabsorption
  • Pancreatic cancer
  • Supportive care
  • Weight loss

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

on behalf of the Precision Promise Consortium (Accepted/In press). Pancreas Cancer-Associated Weight Loss. Oncologist. https://doi.org/10.1634/theoncologist.2018-0266

Pancreas Cancer-Associated Weight Loss. / on behalf of the Precision Promise Consortium.

In: Oncologist, 01.01.2018.

Research output: Contribution to journalArticle

on behalf of the Precision Promise Consortium. / Pancreas Cancer-Associated Weight Loss. In: Oncologist. 2018.
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abstract = "Unintentional weight loss in patients with pancreatic cancer is highly prevalent and contributes to low therapeutic tolerance, reduced quality of life, and overall mortality. Weight loss in pancreatic cancer can be due to anorexia, malabsorption, and/or cachexia. Proper supportive care can stabilize or reverse weight loss in patients and improve outcomes. We review the literature on supportive care relevant to pancreatic cancer patients, and offer evidence-based recommendations that include expert nutritional assessment, counseling, supportive measures to ensure adequate caloric intake, pancreatic enzyme supplementation, nutritional supplement replacement, orexigenic agents, and exercise. Pancreatic Cancer Action Network-supported initiatives will spearhead the dissemination and adoption of these best supportive care practices. Implications for Practice: Weight loss in pancreatic cancer patients is endemic, as 85{\%} of pancreatic cancer patients meet the classic definition of cancer cachexia. Despite its significant prevalence and associated morbidity, there is no established approach to this disease entity. It is believed that this is due to an important knowledge gap in understanding the underlying biology and lack of optimal treatment approaches. This article reviews the literature regarding pancreas cancer-associated weight loss and establishes a new framework from which to view this complex clinical problem. An improved approach and understanding will help educate clinicians, improve clinical care, and provide more clarity for future clinical investigation.",
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