Pancreatic cancer-associated diabetes is an "exosomopathy"

Murray Korc

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Diabetes may be a consequence of pancreatic cancer, preceding cancer diagnosis. The underlying mechanism is the release of exosomes delivering adrenomedullin to β cells, inducing endoplasmic reticulum stress and perturbations in the unfolded protein response, leading to β-cell dysfunction and death. This knowledge could lead to improved diagnostic strategies for pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)1508-1510
Number of pages3
JournalClinical Cancer Research
Volume21
Issue number7
DOIs
StatePublished - Apr 1 2015

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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