Pancreatic cancer-associated diabetes is an "exosomopathy"

Murray Korc

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Diabetes may be a consequence of pancreatic cancer, preceding cancer diagnosis. The underlying mechanism is the release of exosomes delivering adrenomedullin to β cells, inducing endoplasmic reticulum stress and perturbations in the unfolded protein response, leading to β-cell dysfunction and death. This knowledge could lead to improved diagnostic strategies for pancreatic cancer.

Original languageEnglish
Pages (from-to)1508-1510
Number of pages3
JournalClinical Cancer Research
Volume21
Issue number7
DOIs
StatePublished - Apr 1 2015

Fingerprint

Pancreatic Neoplasms
Exosomes
Adrenomedullin
Unfolded Protein Response
Endoplasmic Reticulum Stress
Cell Death
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pancreatic cancer-associated diabetes is an "exosomopathy". / Korc, Murray.

In: Clinical Cancer Research, Vol. 21, No. 7, 01.04.2015, p. 1508-1510.

Research output: Contribution to journalArticle

Korc, Murray. / Pancreatic cancer-associated diabetes is an "exosomopathy". In: Clinical Cancer Research. 2015 ; Vol. 21, No. 7. pp. 1508-1510.
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