Pancreatic cancer-associated stroma production

Murray Korc

Research output: Contribution to journalArticle

181 Citations (Scopus)

Abstract

One of the defining features of pancreatic ductal adenocarcinoma (PDAC) is the presence of extensive desmoplasia. The desmoplastic stroma consists of proliferating fibroblasts and pancreatic stellate cells that produce and deposit fibronectin and collagens, inflammatory cells and macrophages that produce chemokines and cyokines, nerve fibers that release nerve growth factors, and marrow-derived stem cells. Stroma production is facilitated by the abundance of growth factors, including fibroblast growth factors (FGFs), epidermal growth factor (EGF) receptor ligands, transforming growth factor-β (TGF-β) isoforms, and connective tissue growth factor. Due to its location in the pancreas, stromal cells and pancreatic cancer cells are also exposed to high insulin levels. The stromal compartment stores and synthesizes multiple growth factors and the heparan sulfate proteoglycans glypican-1 and syndecan-1. This unique microenvironment harbors and nourishes the cancer cells, facilitating their invasive and metastatic potential. Targeting the stroma may thus provide novel therapeutic options in this deadly malignancy.

Original languageEnglish (US)
JournalAmerican Journal of Surgery
Volume194
Issue number4 SUPPL.
DOIs
StatePublished - Oct 2007
Externally publishedYes

Fingerprint

Pancreatic Neoplasms
Intercellular Signaling Peptides and Proteins
Pancreatic Stellate Cells
Glypicans
Syndecan-1
Connective Tissue Growth Factor
Heparan Sulfate Proteoglycans
Fibroblast Growth Factors
Nerve Growth Factors
Transforming Growth Factors
Stromal Cells
Nerve Fibers
Fibronectins
Chemokines
Epidermal Growth Factor Receptor
Pancreas
Neoplasms
Protein Isoforms
Adenocarcinoma
Collagen

Keywords

  • Growth factors
  • Heparan sulfate proteoglycans
  • Pancreatic cancer
  • Stroma
  • Targeted therapy
  • Tumor microenvironment

ASJC Scopus subject areas

  • Surgery

Cite this

Pancreatic cancer-associated stroma production. / Korc, Murray.

In: American Journal of Surgery, Vol. 194, No. 4 SUPPL., 10.2007.

Research output: Contribution to journalArticle

Korc, Murray. / Pancreatic cancer-associated stroma production. In: American Journal of Surgery. 2007 ; Vol. 194, No. 4 SUPPL.
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