Abstract
One of the defining features of pancreatic ductal adenocarcinoma (PDAC) is the presence of extensive desmoplasia. The desmoplastic stroma consists of proliferating fibroblasts and pancreatic stellate cells that produce and deposit fibronectin and collagens, inflammatory cells and macrophages that produce chemokines and cyokines, nerve fibers that release nerve growth factors, and marrow-derived stem cells. Stroma production is facilitated by the abundance of growth factors, including fibroblast growth factors (FGFs), epidermal growth factor (EGF) receptor ligands, transforming growth factor-β (TGF-β) isoforms, and connective tissue growth factor. Due to its location in the pancreas, stromal cells and pancreatic cancer cells are also exposed to high insulin levels. The stromal compartment stores and synthesizes multiple growth factors and the heparan sulfate proteoglycans glypican-1 and syndecan-1. This unique microenvironment harbors and nourishes the cancer cells, facilitating their invasive and metastatic potential. Targeting the stroma may thus provide novel therapeutic options in this deadly malignancy.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Surgery |
| Volume | 194 |
| Issue number | 4 SUPPL. |
| DOIs | |
| State | Published - Oct 2007 |
| Externally published | Yes |
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Keywords
- Growth factors
- Heparan sulfate proteoglycans
- Pancreatic cancer
- Stroma
- Targeted therapy
- Tumor microenvironment
ASJC Scopus subject areas
- Surgery
Cite this
Pancreatic cancer-associated stroma production. / Korc, Murray.
In: American Journal of Surgery, Vol. 194, No. 4 SUPPL., 10.2007.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pancreatic cancer-associated stroma production
AU - Korc, Murray
PY - 2007/10
Y1 - 2007/10
N2 - One of the defining features of pancreatic ductal adenocarcinoma (PDAC) is the presence of extensive desmoplasia. The desmoplastic stroma consists of proliferating fibroblasts and pancreatic stellate cells that produce and deposit fibronectin and collagens, inflammatory cells and macrophages that produce chemokines and cyokines, nerve fibers that release nerve growth factors, and marrow-derived stem cells. Stroma production is facilitated by the abundance of growth factors, including fibroblast growth factors (FGFs), epidermal growth factor (EGF) receptor ligands, transforming growth factor-β (TGF-β) isoforms, and connective tissue growth factor. Due to its location in the pancreas, stromal cells and pancreatic cancer cells are also exposed to high insulin levels. The stromal compartment stores and synthesizes multiple growth factors and the heparan sulfate proteoglycans glypican-1 and syndecan-1. This unique microenvironment harbors and nourishes the cancer cells, facilitating their invasive and metastatic potential. Targeting the stroma may thus provide novel therapeutic options in this deadly malignancy.
AB - One of the defining features of pancreatic ductal adenocarcinoma (PDAC) is the presence of extensive desmoplasia. The desmoplastic stroma consists of proliferating fibroblasts and pancreatic stellate cells that produce and deposit fibronectin and collagens, inflammatory cells and macrophages that produce chemokines and cyokines, nerve fibers that release nerve growth factors, and marrow-derived stem cells. Stroma production is facilitated by the abundance of growth factors, including fibroblast growth factors (FGFs), epidermal growth factor (EGF) receptor ligands, transforming growth factor-β (TGF-β) isoforms, and connective tissue growth factor. Due to its location in the pancreas, stromal cells and pancreatic cancer cells are also exposed to high insulin levels. The stromal compartment stores and synthesizes multiple growth factors and the heparan sulfate proteoglycans glypican-1 and syndecan-1. This unique microenvironment harbors and nourishes the cancer cells, facilitating their invasive and metastatic potential. Targeting the stroma may thus provide novel therapeutic options in this deadly malignancy.
KW - Growth factors
KW - Heparan sulfate proteoglycans
KW - Pancreatic cancer
KW - Stroma
KW - Targeted therapy
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=34648852355&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34648852355&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2007.05.004
DO - 10.1016/j.amjsurg.2007.05.004
M3 - Article
C2 - 17903452
AN - SCOPUS:34648852355
VL - 194
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 4 SUPPL.
ER -