Pancreatic cancer: The potential clinical relevance of alterations in growth factors and their receptors

H. Friess, P. Berberat, M. Schilling, J. Kunz, M. Korc, M. W. Büchler

Research output: Contribution to journalReview article

109 Scopus citations

Abstract

Molecular alterations play a key role in the pathogenesis of gastrointestinal cancers. In the present paper we describe relevant molecular alterations in human pancreatic adenocarcinomas. Overexpression of growth factor receptors (EGF receptor, c-erbB2, c-erbB3, TGFβ receptor I-III), growth factors (EGF, TGFα, TGFβ-1-3, aFGF, bFGF), adhesion molecules (ICAM-1, ELAM-1) and gene mutations (p53, K-ras, DCC, APC) are present in a significant number of these tumors. These changes stimulate tumor growth and enhance the metastatic behavior of pancreatic cancer cells and thereby may contribute to shorter postoperative survival following tumor resection.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
JournalJournal of Molecular Medicine
Volume74
Issue number1
DOIs
StatePublished - Jan 1 1996

Keywords

  • Adhesion molecules
  • Gene mutations
  • Growth factor receptors
  • Growth factors
  • Pancreatic cancer

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Genetics(clinical)

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