Pancreatic cancer: The potential clinical relevance of alterations in growth factors and their receptors

H. Friess, P. Berberat, M. Schilling, J. Kunz, Murray Korc, M. W. Büchler

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Molecular alterations play a key role in the pathogenesis of gastrointestinal cancers. In the present paper we describe relevant molecular alterations in human pancreatic adenocarcinomas. Overexpression of growth factor receptors (EGF receptor, c-erbB2, c-erbB3, TGFβ receptor I-III), growth factors (EGF, TGFα, TGFβ-1-3, aFGF, bFGF), adhesion molecules (ICAM-1, ELAM-1) and gene mutations (p53, K-ras, DCC, APC) are present in a significant number of these tumors. These changes stimulate tumor growth and enhance the metastatic behavior of pancreatic cancer cells and thereby may contribute to shorter postoperative survival following tumor resection.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
JournalJournal of Molecular Medicine
Volume74
Issue number1
StatePublished - 1996
Externally publishedYes

Fingerprint

Growth Factor Receptors
Pancreatic Neoplasms
Neoplasms
Gastrointestinal Neoplasms
E-Selectin
p53 Genes
Intercellular Adhesion Molecule-1
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Intercellular Signaling Peptides and Proteins
Adenocarcinoma
Mutation
Survival
Growth

Keywords

  • Adhesion molecules
  • Gene mutations
  • Growth factor receptors
  • Growth factors
  • Pancreatic cancer

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Friess, H., Berberat, P., Schilling, M., Kunz, J., Korc, M., & Büchler, M. W. (1996). Pancreatic cancer: The potential clinical relevance of alterations in growth factors and their receptors. Journal of Molecular Medicine, 74(1), 35-42.

Pancreatic cancer : The potential clinical relevance of alterations in growth factors and their receptors. / Friess, H.; Berberat, P.; Schilling, M.; Kunz, J.; Korc, Murray; Büchler, M. W.

In: Journal of Molecular Medicine, Vol. 74, No. 1, 1996, p. 35-42.

Research output: Contribution to journalArticle

Friess, H, Berberat, P, Schilling, M, Kunz, J, Korc, M & Büchler, MW 1996, 'Pancreatic cancer: The potential clinical relevance of alterations in growth factors and their receptors', Journal of Molecular Medicine, vol. 74, no. 1, pp. 35-42.
Friess, H. ; Berberat, P. ; Schilling, M. ; Kunz, J. ; Korc, Murray ; Büchler, M. W. / Pancreatic cancer : The potential clinical relevance of alterations in growth factors and their receptors. In: Journal of Molecular Medicine. 1996 ; Vol. 74, No. 1. pp. 35-42.
@article{4370c20812aa43738a6be05d82050072,
title = "Pancreatic cancer: The potential clinical relevance of alterations in growth factors and their receptors",
abstract = "Molecular alterations play a key role in the pathogenesis of gastrointestinal cancers. In the present paper we describe relevant molecular alterations in human pancreatic adenocarcinomas. Overexpression of growth factor receptors (EGF receptor, c-erbB2, c-erbB3, TGFβ receptor I-III), growth factors (EGF, TGFα, TGFβ-1-3, aFGF, bFGF), adhesion molecules (ICAM-1, ELAM-1) and gene mutations (p53, K-ras, DCC, APC) are present in a significant number of these tumors. These changes stimulate tumor growth and enhance the metastatic behavior of pancreatic cancer cells and thereby may contribute to shorter postoperative survival following tumor resection.",
keywords = "Adhesion molecules, Gene mutations, Growth factor receptors, Growth factors, Pancreatic cancer",
author = "H. Friess and P. Berberat and M. Schilling and J. Kunz and Murray Korc and B{\"u}chler, {M. W.}",
year = "1996",
language = "English (US)",
volume = "74",
pages = "35--42",
journal = "Journal of Molecular Medicine",
issn = "0946-2716",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Pancreatic cancer

T2 - The potential clinical relevance of alterations in growth factors and their receptors

AU - Friess, H.

AU - Berberat, P.

AU - Schilling, M.

AU - Kunz, J.

AU - Korc, Murray

AU - Büchler, M. W.

PY - 1996

Y1 - 1996

N2 - Molecular alterations play a key role in the pathogenesis of gastrointestinal cancers. In the present paper we describe relevant molecular alterations in human pancreatic adenocarcinomas. Overexpression of growth factor receptors (EGF receptor, c-erbB2, c-erbB3, TGFβ receptor I-III), growth factors (EGF, TGFα, TGFβ-1-3, aFGF, bFGF), adhesion molecules (ICAM-1, ELAM-1) and gene mutations (p53, K-ras, DCC, APC) are present in a significant number of these tumors. These changes stimulate tumor growth and enhance the metastatic behavior of pancreatic cancer cells and thereby may contribute to shorter postoperative survival following tumor resection.

AB - Molecular alterations play a key role in the pathogenesis of gastrointestinal cancers. In the present paper we describe relevant molecular alterations in human pancreatic adenocarcinomas. Overexpression of growth factor receptors (EGF receptor, c-erbB2, c-erbB3, TGFβ receptor I-III), growth factors (EGF, TGFα, TGFβ-1-3, aFGF, bFGF), adhesion molecules (ICAM-1, ELAM-1) and gene mutations (p53, K-ras, DCC, APC) are present in a significant number of these tumors. These changes stimulate tumor growth and enhance the metastatic behavior of pancreatic cancer cells and thereby may contribute to shorter postoperative survival following tumor resection.

KW - Adhesion molecules

KW - Gene mutations

KW - Growth factor receptors

KW - Growth factors

KW - Pancreatic cancer

UR - http://www.scopus.com/inward/record.url?scp=0030024411&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030024411&partnerID=8YFLogxK

M3 - Article

C2 - 8834768

AN - SCOPUS:0030024411

VL - 74

SP - 35

EP - 42

JO - Journal of Molecular Medicine

JF - Journal of Molecular Medicine

SN - 0946-2716

IS - 1

ER -