Pancreatic disorders in infancy and childhood: Experience with 92 cases

D. W. Vane, J. L. Grosfeld, K. W. West, Frederick Rescorla

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Ninety-two children with pancreatic disorders were treated over a 10-year period. Thirty-three had blunt trauma, while 69 had medical, metabolic, or neoplastic diseases. Children with trauma had either duct disruption (3), gland fracture (4), or pseudocysts formation (26). Operation was required in 30. Pseudocysts were treated with observation alone in three cases, ultrasound-guided percutaneous aspiration in three, surgical external drain-age in two, distal pancreatectomy in four, cyst gastrostomy in ten, and cyst-Roux-en-Y jejunostomy in six. Other disorders included pancreatitis (44), neoplasms (10), nesidioblastosis (4), and pancreaticosplenic abscess (2). Treatment for neoplasms included surgical excision in nine and biopsy in one (adenocarcinoma). Patients with nesidioblastosis underwent 95% (near total) pancreatic resection (two after previous unsuccessful 80% resection). Pancreatitis was familial in two cases, necrotizing in two, idiopathic in 11, and secondary to medications in six cases (steroids, 2; L-asparaginase, 4), gallstones in 17, and choledochal cysts in 6. Pancreatitis resolved after observation and conservative therapy in ten idiopathic cases, 4/6 medication-related cases, and following correction of biliary tract disease (15/17) or choledochal cysts (6). Pancreatic resection or drainage was required in the remaining cases. Pancreatic disorders can be accurately detected with computed tomography (CT) scan in most cases (excluding insulinoma). Ultrasound (US) is useful in cases of biliary tract disease and pseudocyst formation. Traumatic pseudocysts can resolve spontaneously or with US-guided percutaneous drainage (in the presence of normal ducts). Children with neoplasms, abnormal pancreatic ducts, or recurrent pancreatitis require resection or appropriate drainage procedures. Overall survival was 95%.

Original languageEnglish
Pages (from-to)771-776
Number of pages6
JournalJournal of Pediatric Surgery
Volume24
Issue number8
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Nesidioblastosis
Pancreatitis
Biliary Tract Diseases
Choledochal Cyst
Drainage
Cysts
Observation
Jejunostomy
Asparaginase
Neoplasms
Insulinoma
Pancreatectomy
Gastrostomy
Pancreatic Ducts
Wounds and Injuries
Gallstones
Abscess
Adenocarcinoma
Steroids
Tomography

Keywords

  • insulinoma
  • nesidioblastosis
  • pancreatic pseudocyst
  • pancreatic trauma
  • Pancreatitis in childhood

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Pancreatic disorders in infancy and childhood : Experience with 92 cases. / Vane, D. W.; Grosfeld, J. L.; West, K. W.; Rescorla, Frederick.

In: Journal of Pediatric Surgery, Vol. 24, No. 8, 1989, p. 771-776.

Research output: Contribution to journalArticle

Vane, D. W. ; Grosfeld, J. L. ; West, K. W. ; Rescorla, Frederick. / Pancreatic disorders in infancy and childhood : Experience with 92 cases. In: Journal of Pediatric Surgery. 1989 ; Vol. 24, No. 8. pp. 771-776.
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abstract = "Ninety-two children with pancreatic disorders were treated over a 10-year period. Thirty-three had blunt trauma, while 69 had medical, metabolic, or neoplastic diseases. Children with trauma had either duct disruption (3), gland fracture (4), or pseudocysts formation (26). Operation was required in 30. Pseudocysts were treated with observation alone in three cases, ultrasound-guided percutaneous aspiration in three, surgical external drain-age in two, distal pancreatectomy in four, cyst gastrostomy in ten, and cyst-Roux-en-Y jejunostomy in six. Other disorders included pancreatitis (44), neoplasms (10), nesidioblastosis (4), and pancreaticosplenic abscess (2). Treatment for neoplasms included surgical excision in nine and biopsy in one (adenocarcinoma). Patients with nesidioblastosis underwent 95{\%} (near total) pancreatic resection (two after previous unsuccessful 80{\%} resection). Pancreatitis was familial in two cases, necrotizing in two, idiopathic in 11, and secondary to medications in six cases (steroids, 2; L-asparaginase, 4), gallstones in 17, and choledochal cysts in 6. Pancreatitis resolved after observation and conservative therapy in ten idiopathic cases, 4/6 medication-related cases, and following correction of biliary tract disease (15/17) or choledochal cysts (6). Pancreatic resection or drainage was required in the remaining cases. Pancreatic disorders can be accurately detected with computed tomography (CT) scan in most cases (excluding insulinoma). Ultrasound (US) is useful in cases of biliary tract disease and pseudocyst formation. Traumatic pseudocysts can resolve spontaneously or with US-guided percutaneous drainage (in the presence of normal ducts). Children with neoplasms, abnormal pancreatic ducts, or recurrent pancreatitis require resection or appropriate drainage procedures. Overall survival was 95{\%}.",
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