Pancreatic fine-needle aspiration cytology in patients < 35-years of age

A retrospective review of 174 cases spanning a 17-year period

Megan Redelman, Harvey Cramer, Howard Wu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Pancreatic lesions in young patients are relatively rare and, to our knowledge, the clinical value of pancreatic fine needle aspiration (FNA) in patients < 35 years of age has not been previously established by any other large retrospective studies. All pancreatic endoscopic ultrasound-guided FNA (EUS-FNA) cases performed on patients < 35 years of age were identified for a 17-year period (1994-2010). All FNAs and all available correlating surgical pathology reports were reviewed. There were a total of 174 cases of pancreatic FNA performed on 109 females and 65 males under the age of 35 (range: 8-34, mean: 27 years). The FNA diagnoses included 37 malignant, 114 negative, nine atypia/suspicious, and 14 cases that were nondiagnostic. Of the 37 malignant FNA cases, the diagnoses included 18 pancreatic neuroendocrine tumors (PanNeT), 11 solid pseudopapillary neoplasms (SPN), five adenocarcinomas and three metastatic neoplasms. Histologic follow-up was available in 22 of the 37 malignant cases diagnosed by FNA, and the diagnosis was confirmed in 21 cases. One pancreatoblastoma was misclassified as SPN on EUS-FNA. False negative diagnoses were noted in three cases of low-grade mucinous cystic neoplasm and one case of PanNeT. The most common type of neoplasms diagnosed by EUS-FNA in patients < 35-year old is PanNeT, followed by SPN with both tumors accounting for 75% of all the neoplasms encountered in this age group. The sensitivity and specificity for positive cytology in EUS-FNA of the pancreas to identify malignancy and mucinous neoplasms were 90% and 100%, respectively.

Original languageEnglish
Pages (from-to)297-301
Number of pages5
JournalDiagnostic Cytopathology
Volume42
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Fine Needle Biopsy
Cell Biology
Neoplasms
Neuroendocrine Tumors
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Surgical Pathology
Pancreas
Adenocarcinoma
Retrospective Studies
Age Groups
Sensitivity and Specificity

Keywords

  • cytology
  • endoscopic ultrasound
  • fine needle aspiration
  • pancreas
  • young patients

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

@article{3e62c9a99e844dfca79a243b5b4f49de,
title = "Pancreatic fine-needle aspiration cytology in patients < 35-years of age: A retrospective review of 174 cases spanning a 17-year period",
abstract = "Pancreatic lesions in young patients are relatively rare and, to our knowledge, the clinical value of pancreatic fine needle aspiration (FNA) in patients < 35 years of age has not been previously established by any other large retrospective studies. All pancreatic endoscopic ultrasound-guided FNA (EUS-FNA) cases performed on patients < 35 years of age were identified for a 17-year period (1994-2010). All FNAs and all available correlating surgical pathology reports were reviewed. There were a total of 174 cases of pancreatic FNA performed on 109 females and 65 males under the age of 35 (range: 8-34, mean: 27 years). The FNA diagnoses included 37 malignant, 114 negative, nine atypia/suspicious, and 14 cases that were nondiagnostic. Of the 37 malignant FNA cases, the diagnoses included 18 pancreatic neuroendocrine tumors (PanNeT), 11 solid pseudopapillary neoplasms (SPN), five adenocarcinomas and three metastatic neoplasms. Histologic follow-up was available in 22 of the 37 malignant cases diagnosed by FNA, and the diagnosis was confirmed in 21 cases. One pancreatoblastoma was misclassified as SPN on EUS-FNA. False negative diagnoses were noted in three cases of low-grade mucinous cystic neoplasm and one case of PanNeT. The most common type of neoplasms diagnosed by EUS-FNA in patients < 35-year old is PanNeT, followed by SPN with both tumors accounting for 75{\%} of all the neoplasms encountered in this age group. The sensitivity and specificity for positive cytology in EUS-FNA of the pancreas to identify malignancy and mucinous neoplasms were 90{\%} and 100{\%}, respectively.",
keywords = "cytology, endoscopic ultrasound, fine needle aspiration, pancreas, young patients",
author = "Megan Redelman and Harvey Cramer and Howard Wu",
year = "2014",
doi = "10.1002/dc.23070",
language = "English",
volume = "42",
pages = "297--301",
journal = "Diagnostic Cytopathology",
issn = "8755-1039",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Pancreatic fine-needle aspiration cytology in patients < 35-years of age

T2 - A retrospective review of 174 cases spanning a 17-year period

AU - Redelman, Megan

AU - Cramer, Harvey

AU - Wu, Howard

PY - 2014

Y1 - 2014

N2 - Pancreatic lesions in young patients are relatively rare and, to our knowledge, the clinical value of pancreatic fine needle aspiration (FNA) in patients < 35 years of age has not been previously established by any other large retrospective studies. All pancreatic endoscopic ultrasound-guided FNA (EUS-FNA) cases performed on patients < 35 years of age were identified for a 17-year period (1994-2010). All FNAs and all available correlating surgical pathology reports were reviewed. There were a total of 174 cases of pancreatic FNA performed on 109 females and 65 males under the age of 35 (range: 8-34, mean: 27 years). The FNA diagnoses included 37 malignant, 114 negative, nine atypia/suspicious, and 14 cases that were nondiagnostic. Of the 37 malignant FNA cases, the diagnoses included 18 pancreatic neuroendocrine tumors (PanNeT), 11 solid pseudopapillary neoplasms (SPN), five adenocarcinomas and three metastatic neoplasms. Histologic follow-up was available in 22 of the 37 malignant cases diagnosed by FNA, and the diagnosis was confirmed in 21 cases. One pancreatoblastoma was misclassified as SPN on EUS-FNA. False negative diagnoses were noted in three cases of low-grade mucinous cystic neoplasm and one case of PanNeT. The most common type of neoplasms diagnosed by EUS-FNA in patients < 35-year old is PanNeT, followed by SPN with both tumors accounting for 75% of all the neoplasms encountered in this age group. The sensitivity and specificity for positive cytology in EUS-FNA of the pancreas to identify malignancy and mucinous neoplasms were 90% and 100%, respectively.

AB - Pancreatic lesions in young patients are relatively rare and, to our knowledge, the clinical value of pancreatic fine needle aspiration (FNA) in patients < 35 years of age has not been previously established by any other large retrospective studies. All pancreatic endoscopic ultrasound-guided FNA (EUS-FNA) cases performed on patients < 35 years of age were identified for a 17-year period (1994-2010). All FNAs and all available correlating surgical pathology reports were reviewed. There were a total of 174 cases of pancreatic FNA performed on 109 females and 65 males under the age of 35 (range: 8-34, mean: 27 years). The FNA diagnoses included 37 malignant, 114 negative, nine atypia/suspicious, and 14 cases that were nondiagnostic. Of the 37 malignant FNA cases, the diagnoses included 18 pancreatic neuroendocrine tumors (PanNeT), 11 solid pseudopapillary neoplasms (SPN), five adenocarcinomas and three metastatic neoplasms. Histologic follow-up was available in 22 of the 37 malignant cases diagnosed by FNA, and the diagnosis was confirmed in 21 cases. One pancreatoblastoma was misclassified as SPN on EUS-FNA. False negative diagnoses were noted in three cases of low-grade mucinous cystic neoplasm and one case of PanNeT. The most common type of neoplasms diagnosed by EUS-FNA in patients < 35-year old is PanNeT, followed by SPN with both tumors accounting for 75% of all the neoplasms encountered in this age group. The sensitivity and specificity for positive cytology in EUS-FNA of the pancreas to identify malignancy and mucinous neoplasms were 90% and 100%, respectively.

KW - cytology

KW - endoscopic ultrasound

KW - fine needle aspiration

KW - pancreas

KW - young patients

UR - http://www.scopus.com/inward/record.url?scp=84896397636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896397636&partnerID=8YFLogxK

U2 - 10.1002/dc.23070

DO - 10.1002/dc.23070

M3 - Article

VL - 42

SP - 297

EP - 301

JO - Diagnostic Cytopathology

JF - Diagnostic Cytopathology

SN - 8755-1039

IS - 4

ER -