Pancreatic polypeptide Immunoreactivity in sporadic Gastrinoma: Relationship to Intraabdominal location

Thomas J. Howard, Mark Sawicki, Klaus J. Lewin, Barbara Steel, Belur S. Bhagavan, Oscar W. Cummings, Edward Passaro

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Sporadic gastrinoma is a pancreatic endocrine tumor whose ontogeny is unknown. The anatomic area where the vast majority of sporadic gastrinomas is found (pancreatic head region) corresponds topographically to the area traversed embryologically by the ventral pancreatic bud. Pancreatic polypeptide (PP), a 36-amino acid hormone, is secreted by pancreatic endocrine cells derived almost exclusively from the ventral pancreatic bud and is proposed as a marker for ventral bud derivation. Based on these observations we postulate that sporadic gastrinomas, found around the head of the pancreas, are derived from ventral bud tissue and should display a high incidence of PP immunoreactivity. Overall, we found PP immunoreactivity in 7 of 14 (50%) gastrinomas. Of thosetumors located to the right of the superior mesenteric artery (SMA) (around the head of the pancreas), seven of nine (78%) contained PP, whereas no gastrinoma to the left of the SMA (n = 5) contained PP (p = 0.021; Fisher exact test). Only one other pancreatic endocrine or exocrine tumor, a glucagonoma located to the left of the SMA, stained positively for PP. We conclude that sporadic gastrinomas found around the head of the pancreas (to the right of the SMA) have a high incidence of PP immunoreactivity. These findings are consistent with our hypothesis that sporadic gastrinomas are derived from the ventral pancreatic bud.

Original languageEnglish (US)
Pages (from-to)350-356
Number of pages7
JournalPancreas
Volume11
Issue number4
DOIs
StatePublished - Nov 1995

Keywords

  • Gastrinoma
  • Gastrinoma triangle
  • Pancreatic polypeptide
  • Superior mesenteric artery
  • Ventral pancreatic bud

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Internal Medicine
  • Gastroenterology

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