Pancreatic Steatosis Promotes Dissemination and Lethality of Pancreatic Cancer

Abhishek Mathur, Nicholas Zyromski, Henry A. Pitt, Hayder Al-Azzawi, Julia J. Walker, Romil Saxena, Keith D. Lillemoe

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Abstract

Background: Obesity is a worldwide epidemic. Clinical and basic studies have shown obesity to be associated with an increased incidence and progression of pancreatic cancer. The precise role that pancreatic fat plays in this process has remained undefined. We tested the hypothesis that pancreatic steatosis would be associated with increased dissemination and reduced survival in patients with resected pancreatic cancer. Study Design: A case-control analysis was conducted in patients who had undergone resection for pancreatic adenocarcinoma. Twenty lymph node-positive patients and 20 node-negative patients were matched for age (59 versus 63 years), gender (70% male versus 60% male), body mass index (24.5 versus 25.6), medical comorbidities (hypertension, diabetes, hyperlipidemia), tumor size (2.8 versus 2.6 cm), and resection status (Ro 80% versus 85%). Pancreatic neck margins were reviewed in a blinded fashion by two trained investigators. Pancreatic fat (number of cells/5 high power field) and degree of fibrosis (0 to 4+) were recorded. Results: Node-positive patients had significantly more fat cells in the pancreas compared with node-negative patients (46.4 ± 8.7 versus 21.4 ± 4.8; p < 0.02). Node-positive patients also demonstrated decreased fibrosis compared with node-negative patients (1.7 ± 0.3 versus 2.7 ± 0.3; p < 0.02). Mean survival was reduced in node-positive patients (18.9 ± 2.7 versus 30.8 ± 4.8 months; p < 0.04). Conclusions: These data show that increased pancreatic fat promotes dissemination and lethality of pancreatic cancer. We conclude that pancreatic steatosis alters the tumor microenvironment, enhances tumor spread, and contributes to the early demise of patients with pancreatic adenocarcinoma.

Original languageEnglish
Pages (from-to)989-994
Number of pages6
JournalJournal of the American College of Surgeons
Volume208
Issue number5
DOIs
StatePublished - May 2009

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Pancreatic Neoplasms
Adipocytes
Adenocarcinoma
Fibrosis
Obesity
Fats
Tumor Microenvironment
Survival
Hyperlipidemias
Comorbidity
Pancreas
Neoplasms
Body Mass Index
Lymph Nodes
Research Personnel
Hypertension
Incidence

ASJC Scopus subject areas

  • Surgery

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Pancreatic Steatosis Promotes Dissemination and Lethality of Pancreatic Cancer. / Mathur, Abhishek; Zyromski, Nicholas; Pitt, Henry A.; Al-Azzawi, Hayder; Walker, Julia J.; Saxena, Romil; Lillemoe, Keith D.

In: Journal of the American College of Surgeons, Vol. 208, No. 5, 05.2009, p. 989-994.

Research output: Contribution to journalArticle

Mathur, Abhishek ; Zyromski, Nicholas ; Pitt, Henry A. ; Al-Azzawi, Hayder ; Walker, Julia J. ; Saxena, Romil ; Lillemoe, Keith D. / Pancreatic Steatosis Promotes Dissemination and Lethality of Pancreatic Cancer. In: Journal of the American College of Surgeons. 2009 ; Vol. 208, No. 5. pp. 989-994.
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