Pancreatitis and cystic fibrosis gene mutations

C. P. Choudari, Glen Lehman, Stuart Sherman

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Cystic fibrosis (CF) is a genetic disease with multisystem involvement in which defective chloride transport across membranes causes dehydrated secretions. The protein encoded by the CF gene - the cystic fibrosis transmembrane conductance regulator (CFTR) gene - functions as a cyclic adenosine monophosphate-regulated chloride channel. The ability to detect CFTR mutations has led to the recognition of its association with a variety of conditions, including chronic bronchitis, sinusitis with nasal polyps, pancreatitis, and, in men, infertility. This article reviews the impact of CF on the pancreas, the role of the CFTR protein in pancreatic secretion, and some of the exciting research identifying mutations in the CFTR gene as a risk factor for idiopathic acute and chronic pancreatitis.

Original languageEnglish
Pages (from-to)543-549
Number of pages7
JournalGastroenterology Clinics of North America
Volume28
Issue number3
DOIs
StatePublished - 1999

Fingerprint

Cystic Fibrosis Transmembrane Conductance Regulator
Cystic Fibrosis
Pancreatitis
Mutation
Regulator Genes
Genes
Nasal Polyps
Inborn Genetic Diseases
Chloride Channels
Chronic Bronchitis
Sinusitis
Chronic Pancreatitis
Cyclic AMP
Infertility
Chlorides
Proteins
Membranes
Research

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Pancreatitis and cystic fibrosis gene mutations. / Choudari, C. P.; Lehman, Glen; Sherman, Stuart.

In: Gastroenterology Clinics of North America, Vol. 28, No. 3, 1999, p. 543-549.

Research output: Contribution to journalArticle

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