Panoramic optical imaging of electrical propagation in isolated heart

Shien-Fong Lin, John P. Wikswo

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Optical imaging of cardiac transmembrane potential in dye-stained tissue is an emerging technique in cardiac electrophysiology. Despite its widespread application to studies of isolated hearts, it has been applied traditionally to recording only a single view that presents the potential distribution of a fraction of the cardiac surface. This poses a significant limitation in studying whole heart electrophysiology, particularly when large-scale phenomena such as fibrillation and defibrillation are of interest. We have developed a panoramic imaging system based on a high-speed charge-coupled device camera with a maximum imaging speed of 335 frame/s at 128×64 pixels/frame. Our system provides one front view and two back mirror views of isolated hearts, thus extending optical imaging capabilities to record from the entire three dimensional heart surface with only one camera.

Original languageEnglish (US)
Pages (from-to)200-207
Number of pages8
JournalJournal of Biomedical Optics
Volume4
Issue number2
DOIs
StatePublished - Apr 1999
Externally publishedYes

Fingerprint

Optical Imaging
electrophysiology
Imaging techniques
propagation
cameras
Cardiac Electrophysiology
fibrillation
Electrophysiology
High speed cameras
CCD cameras
Imaging systems
Membrane Potentials
emerging
charge coupled devices
Mirrors
Coloring Agents
Dyes
dyes
Pixels
recording

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Clinical Biochemistry
  • Atomic and Molecular Physics, and Optics

Cite this

Panoramic optical imaging of electrical propagation in isolated heart. / Lin, Shien-Fong; Wikswo, John P.

In: Journal of Biomedical Optics, Vol. 4, No. 2, 04.1999, p. 200-207.

Research output: Contribution to journalArticle

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