Papillary serous carcinoma of the ovary with squamous differentiation

Thomas M. Ulbright, Lawrence M. Roth, Gregory P. Sutton

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Two cases of serous carcinoma of the ovary with squamous differentiation are described. These neoplasms occurred in two women who were 63 and 46 years old and who presented with International Federation of Gynecology and Obstetrics (FIGO) stage IIB and III disease, respectively. The first tumor recurred following chemotherapy; radiotherapy was given, but the patient died of tumor at 4 years. The second neoplasm did not respond to chemotherapy and caused the patient's death at 2 years. In the first case, the squamous differentiation occurred as compact nests of ovoid to spindle cells intermixed with a papillary serous carcinoma component. The squamous component of the second case developed as single or small groups of enlarged, eosinophilic cells, often multinucleated, within nests of papillary serous carcinoma with typical psammoma bodies. In the latter case, intercellular bridges were identified by light microscopy. Both cases showed squamous features by immunohistochemistry, staining positively for 57-kd keratin, although in the first case but not the second there was also some weaker staining for 54-kd keratin, probably indicating incomplete squamous differentiation with retained glandular features. Electron microscopy in both cases revealed prominent cytoplasmic tonofilaments in the squamous component. These two cases reinforce the concept that squamous differentiation, although more frequent in some other types of common epithelial tumors, may occur in serous ovarian carcinomas as well.

Original languageEnglish (US)
Pages (from-to)86-94
Number of pages9
JournalInternational Journal of Gynecological Pathology
Volume9
Issue number1
DOIs
StatePublished - Feb 1990

Fingerprint

Papillary Carcinoma
Ovary
Keratins
Neoplasms
Staining and Labeling
Carcinoma
Drug Therapy
Second Primary Neoplasms
Intermediate Filaments
Gynecology
Obstetrics
Microscopy
Electron Microscopy
Radiotherapy
Immunohistochemistry
Light

Keywords

  • Keratins
  • Ovarian neoplasm
  • Serous carcinoma
  • Squamous metaplasia

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pathology and Forensic Medicine

Cite this

Papillary serous carcinoma of the ovary with squamous differentiation. / Ulbright, Thomas M.; Roth, Lawrence M.; Sutton, Gregory P.

In: International Journal of Gynecological Pathology, Vol. 9, No. 1, 02.1990, p. 86-94.

Research output: Contribution to journalArticle

@article{003f82a503174bea8c1cb62d47462d09,
title = "Papillary serous carcinoma of the ovary with squamous differentiation",
abstract = "Two cases of serous carcinoma of the ovary with squamous differentiation are described. These neoplasms occurred in two women who were 63 and 46 years old and who presented with International Federation of Gynecology and Obstetrics (FIGO) stage IIB and III disease, respectively. The first tumor recurred following chemotherapy; radiotherapy was given, but the patient died of tumor at 4 years. The second neoplasm did not respond to chemotherapy and caused the patient's death at 2 years. In the first case, the squamous differentiation occurred as compact nests of ovoid to spindle cells intermixed with a papillary serous carcinoma component. The squamous component of the second case developed as single or small groups of enlarged, eosinophilic cells, often multinucleated, within nests of papillary serous carcinoma with typical psammoma bodies. In the latter case, intercellular bridges were identified by light microscopy. Both cases showed squamous features by immunohistochemistry, staining positively for 57-kd keratin, although in the first case but not the second there was also some weaker staining for 54-kd keratin, probably indicating incomplete squamous differentiation with retained glandular features. Electron microscopy in both cases revealed prominent cytoplasmic tonofilaments in the squamous component. These two cases reinforce the concept that squamous differentiation, although more frequent in some other types of common epithelial tumors, may occur in serous ovarian carcinomas as well.",
keywords = "Keratins, Ovarian neoplasm, Serous carcinoma, Squamous metaplasia",
author = "Ulbright, {Thomas M.} and Roth, {Lawrence M.} and Sutton, {Gregory P.}",
year = "1990",
month = "2",
doi = "10.1097/00004347-199001000-00009",
language = "English (US)",
volume = "9",
pages = "86--94",
journal = "International Journal of Gynecological Pathology",
issn = "0277-1691",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Papillary serous carcinoma of the ovary with squamous differentiation

AU - Ulbright, Thomas M.

AU - Roth, Lawrence M.

AU - Sutton, Gregory P.

PY - 1990/2

Y1 - 1990/2

N2 - Two cases of serous carcinoma of the ovary with squamous differentiation are described. These neoplasms occurred in two women who were 63 and 46 years old and who presented with International Federation of Gynecology and Obstetrics (FIGO) stage IIB and III disease, respectively. The first tumor recurred following chemotherapy; radiotherapy was given, but the patient died of tumor at 4 years. The second neoplasm did not respond to chemotherapy and caused the patient's death at 2 years. In the first case, the squamous differentiation occurred as compact nests of ovoid to spindle cells intermixed with a papillary serous carcinoma component. The squamous component of the second case developed as single or small groups of enlarged, eosinophilic cells, often multinucleated, within nests of papillary serous carcinoma with typical psammoma bodies. In the latter case, intercellular bridges were identified by light microscopy. Both cases showed squamous features by immunohistochemistry, staining positively for 57-kd keratin, although in the first case but not the second there was also some weaker staining for 54-kd keratin, probably indicating incomplete squamous differentiation with retained glandular features. Electron microscopy in both cases revealed prominent cytoplasmic tonofilaments in the squamous component. These two cases reinforce the concept that squamous differentiation, although more frequent in some other types of common epithelial tumors, may occur in serous ovarian carcinomas as well.

AB - Two cases of serous carcinoma of the ovary with squamous differentiation are described. These neoplasms occurred in two women who were 63 and 46 years old and who presented with International Federation of Gynecology and Obstetrics (FIGO) stage IIB and III disease, respectively. The first tumor recurred following chemotherapy; radiotherapy was given, but the patient died of tumor at 4 years. The second neoplasm did not respond to chemotherapy and caused the patient's death at 2 years. In the first case, the squamous differentiation occurred as compact nests of ovoid to spindle cells intermixed with a papillary serous carcinoma component. The squamous component of the second case developed as single or small groups of enlarged, eosinophilic cells, often multinucleated, within nests of papillary serous carcinoma with typical psammoma bodies. In the latter case, intercellular bridges were identified by light microscopy. Both cases showed squamous features by immunohistochemistry, staining positively for 57-kd keratin, although in the first case but not the second there was also some weaker staining for 54-kd keratin, probably indicating incomplete squamous differentiation with retained glandular features. Electron microscopy in both cases revealed prominent cytoplasmic tonofilaments in the squamous component. These two cases reinforce the concept that squamous differentiation, although more frequent in some other types of common epithelial tumors, may occur in serous ovarian carcinomas as well.

KW - Keratins

KW - Ovarian neoplasm

KW - Serous carcinoma

KW - Squamous metaplasia

UR - http://www.scopus.com/inward/record.url?scp=0025158990&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025158990&partnerID=8YFLogxK

U2 - 10.1097/00004347-199001000-00009

DO - 10.1097/00004347-199001000-00009

M3 - Article

C2 - 2294067

AN - SCOPUS:0025158990

VL - 9

SP - 86

EP - 94

JO - International Journal of Gynecological Pathology

JF - International Journal of Gynecological Pathology

SN - 0277-1691

IS - 1

ER -