Paracrine interactions govern the progression of lympho-hemopoietic malignancies: Evidence from long-term marrow cultures

H. Boswell, H. Guenter Derigs, Theresa S. Nahreini, Gem S. Burgess

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Original concepts of tumor cell autonomy were influenced by clinical and pathologic criteria recognizing the monotony of a cell population whose normal boundaries had been exceeded in the organism with cancer. These rudimentary concepts, although consistent with the observation of clonal derivation of most lymphohemopoietic malignancies, I-5 have required major revision, with better understanding of the role of growth factors in the interaction of normal and neoplastic lymphohemopoietic stem cells with the supportive environment of the bone marrow. It is now clear that the majority of lymphohemopoietic malignancies, while clonal, are not composed of truly autonomous populations.

Original languageEnglish (US)
Title of host publicationGrowth Regulation and Carcinogenesis
Subtitle of host publicationVolume I
PublisherCRC Press
Pages251-265
Number of pages15
ISBN (Electronic)9781351080774
ISBN (Print)0849359600, 9781315893228
DOIs
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Boswell, H., Derigs, H. G., Nahreini, T. S., & Burgess, G. S. (2018). Paracrine interactions govern the progression of lympho-hemopoietic malignancies: Evidence from long-term marrow cultures. In Growth Regulation and Carcinogenesis: Volume I (pp. 251-265). CRC Press. https://doi.org/10.1201/9781351072328