Parallel cortical networks for volitional control of swallowing in humans

Kristine Mosier, I. Bereznaya

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

A number of studies have demonstrated the involvement of parallel networks in the control of voluntary sequential motor procedures. We sought to determine whether a parallel network organization may be found for complex, sequentially based motor systems that are the product of both voluntary and automatic control processes. Specifically, we sought to determine whether the cortical organizational scheme for voluntary repetitive swallowing in adult humans is characterized by a hierarchical dual-projection model or by modules organized into parallel systems. We utilized functional magnetic resonance imaging (fMRI) to investigate cortical function during normal swallowing tasks in eight healthy human adults. Subjects performed both dry (saliva) and bolus (3 ml/bolus of water) swallows. Activation during swallowing tasks localized to sensorimotor areas (M1, S1, and SMA), S2, premotor cortex, posterior parietal cortex, cingulate gyrus, inferior frontal gyrus, the cerebellum, the insular cortex, auditory cortex, corpus callosum, and the basal ganglia and thalamus. Principal components analysis (PCA) of these regions revealed five functional clusters or modules: (1) sensorimotor areas and cingulate gyrus; (2) inferior frontal gyrus, S2, corpus callosum, basal ganglia and thalamus; (3) premotor cortex and posterior parietal cortex; (4) cerebellum; and (5) insula. Analysis of the functional relationship between these areas demonstrated two parallel loops defined by connections to either the cerebellum or insula and connected through the sensorimotor-cingulate module. Path analysis was performed to test the hypothesis of modules organized into parallel loops versus a hierarchical dual-projection model consisting of two separate, singular hierarchical serial pathways from the sensorimotor cortex or insula to the thalamus. These results support the model of modules organized into parallel loops (P=0.8), but not the hierarchical dual-projection model (P

Original languageEnglish (US)
Pages (from-to)280-289
Number of pages10
JournalExperimental Brain Research
Volume140
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Deglutition
Thalamus
Cerebellum
Parietal Lobe
Corpus Callosum
Gyrus Cinguli
Motor Cortex
Basal Ganglia
Prefrontal Cortex
Swallows
Auditory Cortex
Principal Component Analysis
Saliva
Cerebral Cortex
Magnetic Resonance Imaging
Water
Sensorimotor Cortex

Keywords

  • Human
  • Parallel networks
  • Sequential movement
  • Swallowing

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Parallel cortical networks for volitional control of swallowing in humans. / Mosier, Kristine; Bereznaya, I.

In: Experimental Brain Research, Vol. 140, No. 3, 2001, p. 280-289.

Research output: Contribution to journalArticle

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